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. 2023 Nov;29(11):2401-2403.
doi: 10.3201/eid2911.230984.

Refractory Microascus Bronchopulmonary Infection Treated with Olorofim, France

Emmanuel Faure, Olivier Brugière, Sylvie Colin de Verdiere, Fanny Vuotto, Lucie Limousin, Emilie Cardot, Camille Cordier, Pauline Coulon, Dea Garcia-Hermoso, Olivier Lortholary, Fanny Lanternier

Refractory Microascus Bronchopulmonary Infection Treated with Olorofim, France

Emmanuel Faure et al. Emerg Infect Dis. 2023 Nov.

Abstract

We report 3 cases of successful treatment of Microascus spp. bronchopulmonary infection in a multiple-traumatized patient and 2 lung transplant recipients in France. We emphasize the promising use of olorofim antifungal therapy in a rising context of intrinsically less-susceptible respiratory infections caused by mold.

Keywords: France; M. cirrosus pneumonia; Microascus; Microascus melanosporus; fungi; olorofim; respiratory infections.

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Figures

Figure
Figure
Macroscopic observation of endobronchial Microascus cirrosus lesion in patient in France with refractory microascus bronchopulmonary infection before (A) and after (B) olorofim treatment. Arrows indicate the lesion.
See this image and copyright information in PMC

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