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Review
. 2023 Dec;72(12):2089-2109.
doi: 10.1007/s00011-023-01797-x. Epub 2023 Oct 25.

Application of omics in Sjögren's syndrome

Wenqin He  1   2   3 , Yangyang Lu  1   2   3 , Rongjing Shi  1   2   3 , Qi An  1   2   3 , Jingwen Zhao  1   2   3 , Xinnan Gao  1   2   3 , Liyun Zhang  1   2   3 , Dan Ma  4   5   6   7
Affiliations
Review

Application of omics in Sjögren's syndrome

Wenqin He et al. Inflamm Res. 2023 Dec.

Abstract

Objective: The pathogenesis, diagnosis, and treatment of Sjögren's syndrome (SS) face many challenges, and there is an urgent need to develop new technologies to improve our understanding of SS.

Methods: By searching the literature published domestically and internationally in the past 20 years, this artical reviewed the research of various omics techniques in SS.

Results: Omics technology provided valuable insights into the pathogenesis, early diagnosis, condition and efficacy evaluation of SS. It is helpful to reveal the pathogenesis of the disease and explore new treatment schemes, which will open a new era for the study of SS.

Conclusion: At present, omics research has made some gratifying achievements, but there are still many uncertainties. Therefore, in the future, we should improve research techniques, standardize the collection of samples, and adopt a combination of multi-omics techniques to jointly study the pathogenesis of SS and provide new schemes for its treatment.

Keywords: Genomics; Metabonomics; Microbiomics; Monocytomics; Proteomics; Transcriptomics.

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