Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct;95(10):e29194.
doi: 10.1002/jmv.29194.

First description and phylogenetic analysis of coxsackie virus A non-polio enteroviruses and parechoviruses A in South Sudanese children

Karen Couderé  1 , Kimberley Benschop  2 , Astrid van Steen  1 , Jaco J Verweij  1 , Suzan Pas  1 , Jeroen Cremer  2 , Arthur W D Edridge  3 , Gasim O E Abd-Elfarag  4 , Michaël B van Hensbroek  4 , Dasja Pajkrt  5 , Jean-Luc Murk  1 , Katja C Wolthers  6
Affiliations

First description and phylogenetic analysis of coxsackie virus A non-polio enteroviruses and parechoviruses A in South Sudanese children

Karen Couderé et al. J Med Virol. 2023 Oct.

Abstract

Enteroviruses (EV) and parechoviruses A (PeV-A) are commonly circulating viruses able to cause severe disease. Surveillance studies from sub-Saharan Africa are limited and show high but variable infection rates and a high variation in genotypes. This is the first study to describe EV and PeV-A circulation in children in South Sudan. Of the fecal samples collected, 35% and 10% were positive for EV and PeV-A, respectively. A wide range of genotypes were found, including several rarely described EV and PeV-A types. Coxsackie virus A (CVA) EV-C types, particularly CVA13, were the most dominant EV types. The CVA13 types had a high diversity with the majority belonging to four different previously described clusters. PeV-A1 and -A14 were the most common PeV-A genotypes. A lack of representative data from our and other studies from sub-Saharan Africa demonstrates the need for more systematic surveillance of non-polio EV and PeV-A types in this region.

Keywords: coxsackievirus A 13; enterovirus; parechovirus A; south Sudan; sub-Saharan Africa; surveillance.

PubMed Disclaimer

References

REFERENCES

    1. Picornaviridae Study Group. Accessed June 22, 2023. https://www.picornastudygroup.com/types/parechovirus/parechovirus_a.htm
    1. Midgley CM, Watson JT, Nix WA, et al. Severe respiratory illness associated with a nationwide outbreak of enterovirus D68 in the USA (2014): a descriptive epidemiological investigation. Lancet Resp Med. 2015;3(11):879-887.
    1. Gonzalez-Sanz R, Casas-Alba D, Launes C, et al. Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016. Euro Surveill. 2019;24(7):21-29.
    1. Pons-Salort M, Parker EPK, Grassly NC. The epidemiology of non-polio enteroviruses: recent advances and outstanding questions. Curr Opin Infect Dis. 2015;28(5):479-487.
    1. Nelson TM, Vuillermin P, Hodge J, et al. An outbreak of severe infections among Australian infants caused by a novel recombinant strain of human parechovirus type 3. Sci Rep. 2017;7:44423.

LinkOut - more resources