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. 2023 Jul;2(6):229-236.
doi: 10.18609/vac.2023.034. Epub 2023 Jul 12.

Non-mucosal vaccination strategies to enhance mucosal immunity

Lisa A Morici  1 , James B McLachlan  1
Affiliations

Non-mucosal vaccination strategies to enhance mucosal immunity

Lisa A Morici et al. Vaccine Insights. 2023 Jul.

Abstract

The SARS-CoV-2 pandemic has highlighted the need for improved vaccines that can elicit long-lasting mucosal immunity. Although mucosal delivery of vaccines represents a plausible method to enhance mucosal immunity, recent studies utilizing intradermal vaccine delivery or incorporation of unique adjuvants suggest that mucosal immunity may be achieved by vaccination via non-mucosal routes. In this expert insight, we highlight emerging evidence from pre-clinical studies that warrant further mechanistic investigation to improve next-generation vaccines against mucosal pathogens, especially those with pandemic potential.

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Conflict of interest statement

Morici LA discloses she has the following grants/contracts (HDTRA1–19-C0013; NIH 272201800045C; NIH/NIAID R01 AI166756–01). She receives consulting fees and payment for expert testimony from AP Experts LLC. McLachlan JB discloses he has the following grant/contract (NIH 01AI166756). Lastly, Tulane has an issued patent on vaccine adjuvant technology for which Morici LA and McLachlan JB are inventors.AUTHORSHIP & CONFLICT OF INTEREST

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References

    1. Liu L, Johnson HL, Cousens S, Perin J, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 2012; 379(9832), 2151–2161. - PubMed
    1. Kotloff KL, Blackwelder WC, Nasrin D, et al. The global enteric multicenter study (GEMS) of diarrheal disease in infants and young children in developing countries: epidemiologic and clinical methods of the case/control study. Clin. Infect. Dis. 2012; 55 Suppl 4(suppl_4), S232–245. - PMC - PubMed
    1. Dockrell HM, Smith SG. What have we learnt about bcg vaccination in the last 20 years? Front. Immunol. 2017; 8, 1134. - PMC - PubMed
    1. Warfel JM, Zimmerman LI, Merkel TJ. Acellular pertussis vaccines protect against disease but fail to prevent infection and transmission in a nonhuman primate model. Proc. Natl. Acad. Sci. 2014; 111(2), 787–792. - PMC - PubMed
    1. Ravichandran S, Coyle EM, Klenow L, et al. Antibody signature induced by SARS-CoV-2 spike protein immunogens in rabbits. Sci. Transl. Med. 2020, eabc3539. - PMC - PubMed

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