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. 2023 Jul;2(6):229-236.
doi: 10.18609/vac.2023.034. Epub 2023 Jul 12.

Non-mucosal vaccination strategies to enhance mucosal immunity

Lisa A Morici  1 , James B McLachlan  1
Affiliations

Non-mucosal vaccination strategies to enhance mucosal immunity

Lisa A Morici et al. Vaccine Insights. 2023 Jul.

Abstract

The SARS-CoV-2 pandemic has highlighted the need for improved vaccines that can elicit long-lasting mucosal immunity. Although mucosal delivery of vaccines represents a plausible method to enhance mucosal immunity, recent studies utilizing intradermal vaccine delivery or incorporation of unique adjuvants suggest that mucosal immunity may be achieved by vaccination via non-mucosal routes. In this expert insight, we highlight emerging evidence from pre-clinical studies that warrant further mechanistic investigation to improve next-generation vaccines against mucosal pathogens, especially those with pandemic potential.

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Conflict of interest statement

Morici LA discloses she has the following grants/contracts (HDTRA1–19-C0013; NIH 272201800045C; NIH/NIAID R01 AI166756–01). She receives consulting fees and payment for expert testimony from AP Experts LLC. McLachlan JB discloses he has the following grant/contract (NIH 01AI166756). Lastly, Tulane has an issued patent on vaccine adjuvant technology for which Morici LA and McLachlan JB are inventors.AUTHORSHIP & CONFLICT OF INTEREST

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