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Review
. 2023 Oct 10:4:1103497.
doi: 10.3389/fpain.2023.1103497. eCollection 2023.

Medication-overuse headache-a review of different treatment strategies

Abouch Krymchantowski  1 , Carla Jevoux  1 , Ana Gabriela Krymchantowski  1 , Luiza Barbosa Ramos  1 , Jackeline S S Barbosa  1 , Raimundo Pereira Silva-Neto  2
Affiliations
Review

Medication-overuse headache-a review of different treatment strategies

Abouch Krymchantowski et al. Front Pain Res (Lausanne). .

Abstract

Medication-overuse headache (MOH) can develop from primary headaches. MOH is usually the result of overuse of symptomatic medications. It is a noteworthy personal and societal burden. The identification and treatment of patients at risk for MOH is an essential component of MOH management. Medication overuse can be modifiable and can advance from episodic to chronic migraine. Treatment for MOH is complex, and experts in the field have varied views on the most appropriate strategy for MOH treatment. The objective of this review is to give a comprehensive synopsis of the literature for the management of MOH. Treatment strategies, such as detoxification and prevention, are the debatable issues. Medication withdrawal is the foundation for management. The available literature suggested abrupt withdrawal with preventive approaches for early management. Bridging therapy could be useful to get relief from withdrawal symptoms. Multidisciplinary choices proved beneficial in supporting withdrawal and preventing relapse. Worldwide, the termination of overused medications has been observed as a standard treatment strategy; however, patient-specific approaches should be taken.

Keywords: chronic migraine; medication-overuse headache; preventive medications; secondary headache; treatment; withdrawal.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. (2015) 386:743–800. 10.1016/S0140-6736(15)60692-4 - DOI - PMC - PubMed
    1. Lipton RB. Risk factors for and management of medication-overuse headache. Continuum (Minneap Minn). (2015) 21:1118–31. 10.1212/CON.0000000000000216 - DOI - PubMed
    1. Bigal ME, Lipton RB. Excessive acute migraine medication use and migraine progression. Neurology. (2008) 71:1821–28. 10.1212/01.wnl.0000335946.53860.1d - DOI - PubMed
    1. Bigal ME, Serrano D, Buse D, Scher A, Stewart WF, Lipton RB. Acute migraine medications and evolution from episodic to chronic migraine: a longitudinal population-based study. Headache. (2008) 48:1157–68. 10.1111/j.1526-4610.2008.01217.x - DOI - PubMed
    1. Steiner TJ, Stovner LJ, Katsarava Z, Lainez J, Lampl C, Lantéri-Minet M, et al. The impact of headache in Europe: principal results of the Eurolight project. J Headache Pain. (2014) 15:31. 10.1186/1129-2377-15-31 - DOI - PMC - PubMed

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