Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients

Mayumi Hangai¹, Takahisa Kawaguchi², Masatoshi Takagi³, Keitaro Matsuo⁴, Soyoung Jeon⁵, Charleston W K Chiang⁶, Andrew T Dewan⁷, Adam J De Smith⁵, Toshihiko Imamura⁸, Yasuhiro Okamoto⁹, Akiko M Saito¹⁰, Takao Deguchi¹¹, Michiaki Kubo¹², Yoichi Tanaka¹³, Yoko Ayukawa¹⁴, Toshinari Hori¹⁵, Kentaro Ohki¹⁶, Nobutaka Kiyokawa¹⁶, Takeshi Inukai¹⁷, Yuki Arakawa¹⁸, Makiko Mori¹⁸, Daisuke Hasegawa¹⁹, Daisuke Tomizawa¹¹, Hiroko Fukushima²⁰, Yuki Yuza²¹, Yasushi Noguchi²², Yuichi Taneyama²³, Setsuo Ota²⁴, Hiroaki Goto²⁵, Masakatsu Yanagimachi²⁵, Dai Keino²⁵, Kazutoshi Koike²⁶, Daisuke Toyama²⁷, Yozo Nakazawa²⁸, Kozue Nakamura²⁹, Koichi Moriwaki³⁰, Yujin Sekinaka³¹, Daisuke Morita²⁸, Shinsuke Hirabayashi³², Yosuke Hosoya¹⁹, Yuri Yoshimoto³³, Hiroki Yoshihara¹⁹, Miwa Ozawa¹⁹, Shinobu Kobayashi¹⁴, Naho Morisaki¹⁴, Tshewang Gyeltshen³⁴, Osamu Takahashi³⁴, Yukinori Okada³⁵, Makiko Matsuda³⁶, Toshihiro Tanaka³⁶, Johji Inazawa³⁷, Junko Takita³⁸, Yasushi Ishida³⁹, Akira Ohara⁴⁰, Catherine Metayer⁴¹, Joseph L Wiemels⁵, Xiaomei Ma⁷, Shuki Mizutani³, Katsuyoshi Koh¹⁸, Yukihide Momozawa¹², Keizo Horibe¹⁰, Fumihiko Matsuda², Motohiro Kato⁴², Atsushi Manabe³², Kevin Y Urayama⁴³

Affiliations

¹ Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatrics, The University of Tokyo, Tokyo.
² Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto.
³ Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo.
⁴ Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya.
⁵ Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles.
⁶ Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles.
⁷ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven.
⁸ Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto.
⁹ Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima.
¹⁰ Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya.
¹¹ Children's Cancer Center, National Center for Child Health and Development, Tokyo.
¹² Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa.
¹³ Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki.
¹⁴ Department of Social Medicine, National Center for Child Health and Development, Tokyo.
¹⁵ Department of Pediatrics, Aichi Medical University Hospital, Nagoya.
¹⁶ Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo.
¹⁷ Department of Pediatrics, University of Yamanashi, Yamanashi.
¹⁸ Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama.
¹⁹ Department of Pediatrics, St. Luke's International Hospital, Tokyo.
²⁰ Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba.
²¹ Department of Hematology/Oncology, Tokyo Metropolitan Children's Medical Center, Tokyo.
²² Department of Pediatrics, Japanese Red Cross Narita Hospital, Chiba.
²³ Department of Hematology/Oncology, Chiba Children's Hospital, Chiba.
²⁴ Department of Pediatrics, Teikyo University Chiba Medical Center, Chiba.
²⁵ Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama.
²⁶ Division of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito.
²⁷ Division of Pediatrics, Showa University Fujigaoka Hospital, Yokohama.
²⁸ Department of Pediatrics, Shinshu University School of Medicine, Matsumoto.
²⁹ Department of Pediatrics, Teikyo University Hospital, Tokyo.
³⁰ Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Saitama.
³¹ Department of Pediatrics, National Defense Medical College, Saitama.
³² Department of Pediatrics, Hokkaido University, Sapporo.
³³ Department of Pediatrics, National Center for Global Health and Medicine, Tokyo.
³⁴ Graduate School of Public Health, St. Luke's International University, Tokyo.
³⁵ Department of Statistical Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa.
³⁶ Department of Human Genetics and Disease Diversity, Tokyo Medical Dental University, Tokyo.
³⁷ Department of Molecular Cytogenetics, Tokyo Medical and Dental University, Tokyo.
³⁸ Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto.
³⁹ Pediatric Medical Center, Ehime Prefectural Central Hospital, Matsuyama.
⁴⁰ Department of Pediatrics, Toho University, Tokyo.
⁴¹ School of Public Health, University of California Berkeley, Berkeley, California.
⁴² Department of Pediatrics, The University of Tokyo, Tokyo.
⁴³ Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan; Graduate School of Public Health, St. Luke's International University, Tokyo. kevurayama@gmail.com.

PMID: 37881853
PMCID: PMC10985430
DOI: 10.3324/haematol.2023.282914

Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients

Mayumi Hangai et al. Haematologica. 2024.

. 2024 Apr 1;109(4):1247-1252.

doi: 10.3324/haematol.2023.282914.

Authors

Affiliations

¹ Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatrics, The University of Tokyo, Tokyo.
² Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto.
³ Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo.
⁴ Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya.
⁵ Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles.
⁶ Center for Genetic Epidemiology, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, USA; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles.
⁷ Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven.
⁸ Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto.
⁹ Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima.
¹⁰ Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya.
¹¹ Children's Cancer Center, National Center for Child Health and Development, Tokyo.
¹² Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa.
¹³ Division of Medicinal Safety Science, National Institute of Health Sciences, Kawasaki.
¹⁴ Department of Social Medicine, National Center for Child Health and Development, Tokyo.
¹⁵ Department of Pediatrics, Aichi Medical University Hospital, Nagoya.
¹⁶ Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo.
¹⁷ Department of Pediatrics, University of Yamanashi, Yamanashi.
¹⁸ Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama.
¹⁹ Department of Pediatrics, St. Luke's International Hospital, Tokyo.
²⁰ Department of Child Health, Faculty of Medicine, University of Tsukuba, Tsukuba.
²¹ Department of Hematology/Oncology, Tokyo Metropolitan Children's Medical Center, Tokyo.
²² Department of Pediatrics, Japanese Red Cross Narita Hospital, Chiba.
²³ Department of Hematology/Oncology, Chiba Children's Hospital, Chiba.
²⁴ Department of Pediatrics, Teikyo University Chiba Medical Center, Chiba.
²⁵ Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama.
²⁶ Division of Pediatric Hematology and Oncology, Ibaraki Children's Hospital, Mito.
²⁷ Division of Pediatrics, Showa University Fujigaoka Hospital, Yokohama.
²⁸ Department of Pediatrics, Shinshu University School of Medicine, Matsumoto.
²⁹ Department of Pediatrics, Teikyo University Hospital, Tokyo.
³⁰ Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Saitama.
³¹ Department of Pediatrics, National Defense Medical College, Saitama.
³² Department of Pediatrics, Hokkaido University, Sapporo.
³³ Department of Pediatrics, National Center for Global Health and Medicine, Tokyo.
³⁴ Graduate School of Public Health, St. Luke's International University, Tokyo.
³⁵ Department of Statistical Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa.
³⁶ Department of Human Genetics and Disease Diversity, Tokyo Medical Dental University, Tokyo.
³⁷ Department of Molecular Cytogenetics, Tokyo Medical and Dental University, Tokyo.
³⁸ Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto.
³⁹ Pediatric Medical Center, Ehime Prefectural Central Hospital, Matsuyama.
⁴⁰ Department of Pediatrics, Toho University, Tokyo.
⁴¹ School of Public Health, University of California Berkeley, Berkeley, California.
⁴² Department of Pediatrics, The University of Tokyo, Tokyo.
⁴³ Department of Social Medicine, National Center for Child Health and Development, Tokyo, Japan; Graduate School of Public Health, St. Luke's International University, Tokyo. kevurayama@gmail.com.

PMID: 37881853
PMCID: PMC10985430
DOI: 10.3324/haematol.2023.282914

No abstract available

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Figures

**Figure 1.**
**Results of meta-analysis combining the TCCSG and JPLSG genome-wide association analysis results**. (A) The Manhattan plot shows the -log10 (P value) of the logistic regression analysis plotted against the chromosomal position (GRCh37/ hg19). The blue line indicates the genome-wide significant P value threshold of 5x10^-8, and the dotted line was the threshold (1x10^-6) for considering results as suggestive. (B) A quantile-quantile plot of the observed *versus* expected distribution of the -log10 (P value) from the analysis. TCCSG: Tokyo Children Cancer Study Group; JPLSG: Japanese Pediatric Leukemia/Lymphoma Study Group.

See this image and copyright information in PMC

References

1. Hunger SP, Mullighan CG. Acute lymphoblastic leukemia in children. N Engl J Med. 2015;373(16):1541-1552. - PubMed
1. Moriyama T, Relling MV, Yang JJ. Inherited genetic variation in childhood acute lymphoblastic leukemia. Blood. 2015;125(26):3988-3995. - PMC - PubMed
1. Shi Y, Du M, Fang Y, et al. . Identification of a novel susceptibility locus at 16q23.1 associated with childhood acute lymphoblastic leukemia in Han Chinese. Hum Mol Genet. 2016;25(13):2873-2880. - PubMed
1. Urayama KY, Takagi M, Kawaguchi T, et al. . Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese. Sci Rep. 2018;8(1):789. - PMC - PubMed
1. Kato M, Manabe A. Treatment and biology of pediatric acute lymphoblastic leukemia. Pediatr Int. 2018;60(1):4-12. - PubMed

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Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients

Affiliations

Genome-wide assessment of genetic risk loci for childhood acute lymphoblastic leukemia in Japanese patients

Authors

Affiliations

Figures

References

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MeSH terms

Grants and funding

LinkOut - more resources

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