Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Sep 5;7(5):zrad098.
doi: 10.1093/bjsopen/zrad098.

Patient-reported outcome measures and surgery for Crohn's disease: systematic review

Whei J Kim  1 , Mohamad Iskandarani  1 , Carlo A Manzo  2 , Gianluca Pellino  3   4 , Marc Martí Gallostra  3 , Paris P Tekkis  1   2   5 , Valerio Celentano  1   2 , Christos Kontovounisios  1   2   5
Affiliations

Patient-reported outcome measures and surgery for Crohn's disease: systematic review

Whei J Kim et al. BJS Open. .

Abstract

Background/aims: Crohn's disease is an inflammatory bowel disease with up to 50 per cent of patients requiring surgery within 10 years of diagnosis. Patient-reported outcome measures (PROMs) are vital to monitor and assess patient health-related quality of life (HRQoL). This systematic review aims to evaluate PROMs within studies for perioperative Crohn's disease patients.

Methods: Articles from MEDLINE, Embase, Emcare and CINAHL databases were searched to find studies relating to the assessment of HRQoL in perioperative Crohn's disease patients using PROMs and patient-reported experience measures (PREMs) from 1st January 2015 to 22nd October 2023. Bias was assessed using the ROBINS-I tool was used for non-randomized interventional studies and the Cochrane RoB2 tool was used for randomized trials.

Results: 1714 journal articles were filtered down to eight studies. Six studies focused on ileocaecal resection, one on perianal fistulas and one on the effects of cholecystectomy on patients with Crohn's disease. Within these articles, ten different PROM tools were identified (8 measures of HRQoL and 2 measures of functional outcome). Overall improvements in patient HRQoL pre- to postoperative for ileocaecal Crohn's disease were found in both paediatric and adult patients. Outcomes were comparable in patients in remission, with or without stoma, but were worse in patients with a stoma and active disease.

Conclusion: There are significant variations in how PROMs are used to evaluate perioperative Crohn's disease outcomes and a need for consensus on how tools are used. Routine assessments using an internationally accepted online platform can be used to monitor patients and support areas of treatment pathways that require further support to ensure high standards of care. They also enable future statistical comparisons in quantitative reviews and meta-analyses.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
PRISMA 2020 flowchart demonstrating the study selection process
See this image and copyright information in PMC

References

    1. Petagna L, Antonelli A, Ganini C, Bellato V, Campanelli M, Divizia Aet al. Pathophysiology of Crohn’s disease inflammation and recurrence. Biol Direct 2020;15:23. - PMC - PubMed
    1. Eglinton TW, Barclay ML, Gearry RB, Frizelle FA. The spectrum of perianal Crohn’s disease in a population-based cohort. Dis Colon Rectum 2012;55:773–777 - PubMed
    1. Meima-van Praag EM, Buskens CJ, Hompes R, Bemelman WA. Surgical management of Crohn’s disease: a state of the art review. Int J Colorectal Dis 2021;36:1133–1145 - PMC - PubMed
    1. Galandiuk S, Kimberling J, Al-Mishlab T, Stromberg AJ. Perianal Crohn disease: predictors of need for permanent diversion. Ann Surg 2005;241:796–802 - PMC - PubMed
    1. Peyrin-Biroulet L, Loftus EV, Colombel J, Sandborn WJ. The natural history of adult Crohn’s disease in population-based cohorts. Am J Gastroenterol 2010;105:289–297 - PubMed

Publication types