Electromechanical interactions between cell membrane and nuclear envelope: Beyond the standard Schwan's model of biological cells

Abstract

We investigate little-appreciated features of the hierarchical core-shell (CS) models of the electrical, mechanical, and electromechanical interactions between the cell membrane (CM) and nuclear envelope (NE). We first consider a simple model of an individual cell based on a coupled resistor-capacitor (Schwan model (SM)) network and show that the CM, when exposed to ac electric fields, acts as a low pass filter while the NE acts as a wide and asymmetric bandpass filter. We provide a simplified calculation for characteristic time associated with the capacitive charging of the NE and parameterize its range of behavior. We furthermore observe several new features dealing with mechanical analogs of the SM based on elementary spring-damper combinations. The chief merit of these models is that they can predict creep compliance responses of an individual cell under static stress and their effective retardation time constants. Next, we use an alternative and a more accurate CS physical model solved by finite element simulations for which geometrical cell reshaping under electromechanical stress (electrodeformation (ED)) is included in a continuum approach with spatial resolution. We show that under an electric field excitation, the elongated nucleus scales differently compared to the electrodeformed cell.

Keywords: Cell membrane; Core–shell modeling; Creep; Electromechanical stress; Nucleus envelope; Viscoelasticity.