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Comment
. 2023 Nov 24;72(12):2222-2223.
doi: 10.1136/gutjnl-2023-330807.

Pleiotropic role of NOTUM in colorectal cancer

Affiliations
Comment

Pleiotropic role of NOTUM in colorectal cancer

Milou S van Driel et al. Gut. .
No abstract available

Keywords: ADENOCARCINOMA; ADENOMA; INTESTINAL STEM CELL.

PubMed Disclaimer

Conflict of interest statement

Competing interests: LV is an employee of Genentech Inc.

Comment on

References

    1. Fearnhead NS, Britton MP, Bodmer WF. The ABC of APC. Hum Mol Genet 2001;10:721–33. 10.1093/hmg/10.7.721 - DOI - PubMed
    1. Kakugawa S, Langton PF, Zebisch M, et al. . Notum Deacylates WNT proteins to suppress signalling activity. Nature 2015;519:187–92. 10.1038/nature14259 - DOI - PMC - PubMed
    1. Giráldez AJ, Copley RR, Cohen SM. HSPG modification by the secreted enzyme Notum shapes the Wingless Morphogen gradient. Dev Cell 2002;2:667–76. 10.1016/s1534-5807(02)00180-6 - DOI - PubMed
    1. Pentinmikko N, Iqbal S, Mana M, et al. . Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. Nature 2019;571:398–402. 10.1038/s41586-019-1383-0 - DOI - PMC - PubMed
    1. Vermeulen L, Morrissey E, van der Heijden M, et al. . Defining stem cell Dynamics in models of intestinal tumor initiation. Science 2013;342:995–8. 10.1126/science.1243148 - DOI - PubMed

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