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. 2023 Dec;18(12):1502-1514.
doi: 10.1038/s41565-023-01523-y. Epub 2023 Oct 26.

Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model

Sagang Koo #  1   2 , Hee Su Sohn #  2 , Tae Hee Kim #  3   4 , Siyeon Yang  3   5 , Se Youn Jang  3   6 , Seongryeol Ye  3   7 , Boomin Choi  1 , Soo Hyeon Kim  8 , Kyoung Sun Park  8 , Hyun Mu Shin  8   9   10 , Ok Kyu Park  1 , Cheesue Kim  2 , Mikyung Kang  11   12 , Min Soh  1 , Jin Yoo  3 , Dokyoon Kim  13 , Nohyun Lee  14 , Byung-Soo Kim  15   16 , Youngmee Jung  17   18 , Taeghwan Hyeon  19   20
Affiliations

Ceria-vesicle nanohybrid therapeutic for modulation of innate and adaptive immunity in a collagen-induced arthritis model

Sagang Koo et al. Nat Nanotechnol. 2023 Dec.

Erratum in

Abstract

Commencing with the breakdown of immune tolerance, multiple pathogenic factors, including synovial inflammation and harmful cytokines, are conjointly involved in the progression of rheumatoid arthritis. Intervening to mitigate some of these factors can bring a short-term therapeutic effect, but other unresolved factors will continue to aggravate the disease. Here we developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to address multiple factors in rheumatoid arthritis. Each component of this nanohybrid works individually and also synergistically, resulting in comprehensive treatment. Alleviation of inflammation and modulation of the tissue environment into an immunotolerant-favourable state are combined to recover the immune system by bridging innate and adaptive immunity. The therapy is shown to successfully treat and prevent rheumatoid arthritis by relieving the main symptoms and also by restoring the immune system through the induction of regulatory T cells in a mouse model of collagen-induced arthritis.

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