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Review
. 2024:187:107-148.
doi: 10.1007/10_2023_234.

Imprinted Polymers on the Route to Plastibodies for Biomacromolecules (MIPs), Viruses (VIPs), and Cells (CIPs)

Xiaorong Zhang  1 , Aysu Yarman  2 , Mahdien Bagheri  3 , Ibrahim M El-Sherbiny  4   5 , Rabeay Y A Hassan  4   5 , Sevinc Kurbanoglu  6 , Armel Franklin Tadjoung Waffo  7 , Ingo Zebger  7 , Tutku Ceren Karabulut  8 , Frank F Bier  1 , Peter Lieberzeit  9 , Frieder W Scheller  10
Affiliations
Review

Imprinted Polymers on the Route to Plastibodies for Biomacromolecules (MIPs), Viruses (VIPs), and Cells (CIPs)

Xiaorong Zhang et al. Adv Biochem Eng Biotechnol. 2024.

Abstract

Around 30% of the scientific papers published on imprinted polymers describe the recognition of proteins, nucleic acids, viruses, and cells. The straightforward synthesis from only one up to six functional monomers and the simple integration into a sensor are significant advantages as compared with enzymes or antibodies. Furthermore, they can be synthesized against toxic substances and structures of low immunogenicity and allow multi-analyte measurements via multi-template synthesis. The affinity is sufficiently high for protein biomarkers, DNA, viruses, and cells. However, the cross-reactivity of highly abundant proteins is still a challenge.

Keywords: Biomimetic sensors; Cell-Imprinted Polymers (CIPs); MIPs for proteins and nucleic acids; Plastibodies; Virus-Imprinted Polymers (VIPs).

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