Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2023 Oct 1;12(5):785-789.
doi: 10.21037/hbsn-23-180. Epub 2023 Sep 11.

The conclusion of reducing acute rejection after liver transplantation by machine perfusion should be extrapolated with caution

Aijun Liang  1 , Linya Zhang  1 , Junjun Jia  2   3 , Kebo Zhong  1 , Yu Nie  1
Affiliations
Editorial

The conclusion of reducing acute rejection after liver transplantation by machine perfusion should be extrapolated with caution

Aijun Liang et al. Hepatobiliary Surg Nutr. .
No abstract available

Keywords: Acute cellular rejection (ACR); hypothermic oxygenated perfusion (HOPE); liver transplantation (LT); normothermic machine perfusion (NMP); normothermic regional perfusion (NRP).

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://hbsn.amegroups.com/article/view/10.21037/hbsn-23-180/coif). The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Forest plots of ACR in OLT after machine perfusion compared with SCS. MP, machine perfusion; SCS, static cold storage; MH, machine perfusion; CI, confidence interval; NMP, normothermic machine perfusion; HMP, hypothermic machine perfusion; NRP, normothermic regional perfusion; ACR, acute cellular rejection; OLT, orthotopic liver transplantation.
Figure 2
Figure 2
Forest plots of ACR in all types donor-OLT after HMP compared with SCS. HMP, hypothermic machine perfusion; SCS, static cold storage; MH, machine perfusion; CI, confidence interval; ECD, extended/expanded criteria donor; DCD, donation after circulatory death; DBD, donor after brainstem death; ACR, acute cellular rejection; OLT, orthotopic liver transplantation.
See this image and copyright information in PMC

Comment on

References

    1. Schlegel A, Mueller M, Muller X, et al. A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation. J Hepatol 2023;78:783-93. 10.1016/j.jhep.2022.12.030 - DOI - PubMed
    1. Liang A, Jia J, Zhong K, et al. Letter to the editor: Acute rejection after liver transplantation with machine perfusion versus static cold storage: A systematic review and meta-analysis. Hepatology 2023. [Epub ahead of print]. doi: 10.1097/HEP.0000000000000482.10.1097/HEP.0000000000000482 - DOI - DOI - PubMed
    1. Maspero M, Ali K, Cazzaniga B, et al. Acute rejection after liver transplantation with machine perfusion versus static cold storage: A systematic review and meta-analysis. Hepatology 2023;78:835-46. 10.1097/HEP.0000000000000363 - DOI - PubMed
    1. Nasralla D, Coussios CC, Mergental H, et al. A randomized trial of normothermic preservation in liver transplantation. Nature 2018;557:50-6. 10.1038/s41586-018-0047-9 - DOI - PubMed
    1. Muñoz DC, Pérez BS, Martínez MP, et al. Does Normothermic Regional Perfusion Improve the Results of Donation After Circulatory Death Liver Transplantation? Transplant Proc 2020;52:1477-80. 10.1016/j.transproceed.2020.01.088 - DOI - PubMed