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. 2023 Oct 9;14(10):501.
doi: 10.3390/jfb14100501.

Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip

Hongxu Zhang  1   2 , Ming Gao  2 , Xiaoying Tian  2 , Dali Cao  1 , Lili Tan  2
Affiliations

Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip

Hongxu Zhang et al. J Funct Biomater. .

Abstract

The Mg alloy vascular clip has biodegradability and good biocompatibility, which can improve the convenience and safety of clinical application. However, the Mg alloy vascular clip also has some disadvantages, such as an unreasonable structure design and a degradation rate which is too fast. In this study, the process of clamping blood vessels with a biodegradable Mg alloy (Mg-Zn-Nd-Zr and Mg-Zn-Nd) general V-type vascular clip was simulated by finite element simulation software (Abaqus). A new type of vascular clip, the P-type vascular clip, was analyzed and investigated through simulation. The differences between Mg alloy vascular clips of V-type and P-type were analyzed by finite element simulation. In addition, the effects of Zr element on the mechanical properties and corrosion resistance of P-type vascular clips were also investigated to improve the mechanical stability. The results show that during the V-type vascular clip closure of Mg-Zn-Nd-Zr alloy, this clip has some problems, such as uneven distribution of blood vessel stress, crevices in blood vessels and stress concentration. The improved P-type vascular clip has uniform closure, and there is no gap in the blood vessel, which can effectively avoid stress concentration. The improved P-type vascular clip is well closed and can effectively avoid stress concentration. The corrosion resistance of the Mg-Zn-Nd-Zr alloy P-type clip was better than that of the Mg-Zn-Nd alloy P-type clip (degradation rate of 2.02 mm/y and 2.61 mm/y on the 7th day, respectively). Mg-Zn-Nd-Zr alloy The P-type vascular clip remained closed even on the 7th day, which could meet the requirements of clinical application.

Keywords: biodegradable Mg alloy; corrosion resistance; finite element modelling; structural design; vascular clip.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structural size of vascular clip ((a): General V-type clip [16], (b): Improved P-type clip).
Figure 2
Figure 2
Optical microstructure of. Mg-Zn-Nd alloy (a,c) and Mg-Zn-Nd-Zr alloy (b,d). ((a,b): Transverse metallographic diagram; (c,d): Longitudinal metallographic diagram).
Figure 3
Figure 3
SEM micrograph and EDS spectrogram of. Mg-Zn-Nd alloy (a,b) and Mg-Zn-Nd-Zr alloy (c,d) of longitudinal planes and EDS results of position A (c) and B (d).
Figure 4
Figure 4
XRD patterns (a) and magnified images (b) of Mg-Zn-Nd alloy and Mg-Zn-Nd-Zr alloy.
Figure 5
Figure 5
Mechanical properties of Mg-Zn-Nd alloy and Mg-Zn-Nd-Zr alloy. ((a): Stress–strain curves; (b): Tensile strength and elongation).
Figure 6
Figure 6
Stress–Strain analysis of general V-clips (a,b), P-clips (d,e), V-clip vessels (c), P-clip vessels (f) using Abaqus analysis.
Figure 7
Figure 7
Curve graph of vascular stress changes with simulation time for V-clip and P-clip.
Figure 8
Figure 8
Abaqus simulation analysis of Mg-Zn-Nd (a,b,c), Mg-Zn-Nd-Zr (e,f) alloy P-clips. Cloud diagram of PEEQMAX (b,e) and MISESMAX (c,f) of blood vessels ((a): MISESMAX of Mg-Zn-Nd vascular clip; (d): MISESMAX of Mg-Zn-Nd-Zr vascular clip).
Figure 9
Figure 9
Abaqus simulation analysis of the effect of blood pressure on Mg-Zn-Nd (a) and Mg-Zn-Nd-Zr (b) alloy vascular clips.
Figure 10
Figure 10
The pH variation (a) and weight loss (b) of Mg-Zn-Nd-Zr and Mg-Zn-Nd alloy. Vascular clips opening and closing during immersion over 7 days.
Figure 11
Figure 11
Macroscopic (a,c,e,g) and microscopic (SEM) images (b,d,f,h) of Mg-Zn-Nd-Zr (a,b,e,f) and Mg-Zn-Nd (c,d,g,h) vascular clips before and after immersion in SBF for 7 days without acid washing.
Figure 12
Figure 12
XRD patterns of Mg-Zn-Nd-Zr and Mg-Zn-Nd after 7 days of corrosion.
Figure 13
Figure 13
Macroscopic (a,c,e,g) and microscopic (SEM) images (b,d,f,h) of Mg-Zn-Nd-Zr (a,b,e,f) and Mg-Zn-Nd (c,d,g,h) vascular clips before and after immersion in SBF for 7 days after acid washing.
Figure 14
Figure 14
Abaqus simulated curve of stress in V-type and P-type clips. Arc segments with program time.
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