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Comment
. 2023 Dec 11;41(12):2011-2013.
doi: 10.1016/j.ccell.2023.10.005. Epub 2023 Oct 26.

From intestinal metaplasia to gastric cancer: Witnessing the rise of evil over time and space

Cheng Zhang  1 , Xi Jiao  2 , Lin Shen  3
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Comment

From intestinal metaplasia to gastric cancer: Witnessing the rise of evil over time and space

Cheng Zhang et al. Cancer Cell. .
Free article

Abstract

Intestinal metaplasia (IM) is a precancerous lesion associated with increased gastric cancer (GC) risk. However, the molecular characteristics and heterogeneity distinguishing the two stages remain unclear. Huang et al. provide a spatiotemporal insight into the transition from IM to GC, offering the potential for tailored precision prevention strategies for GC.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression.
    Huang KK, Ma H, Chong RHH, Uchihara T, Lian BSX, Zhu F, Sheng T, Srivastava S, Tay ST, Sundar R, Tan ALK, Ong X, Lee M, Ho SWT, Lesluyes T, Ashktorab H, Smoot D, Van Loo P, Chua JS, Ramnarayanan K, Lau LHS, Gotoda T, Kim HS, Ang TL, Khor C, Lee JWJ, Tsao SKK, Yang WL, Teh M, Chung H, So JBY, Yeoh KG, Tan P; Singapore Gastric Cancer Consortium. Huang KK, et al. Cancer Cell. 2023 Dec 11;41(12):2019-2037.e8. doi: 10.1016/j.ccell.2023.10.004. Epub 2023 Oct 26. Cancer Cell. 2023. PMID: 37890493 Free PMC article.

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