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Comment
. 2023 Nov 13;41(11):1849-1851.
doi: 10.1016/j.ccell.2023.10.001. Epub 2023 Oct 26.

Mitochondrial control of antigen presentation in cancer cells

Ruth Soler-Agesta  1 , Alberto Anel  2 , Lorenzo Galluzzi  3
Affiliations
Free article
Comment

Mitochondrial control of antigen presentation in cancer cells

Ruth Soler-Agesta et al. Cancer Cell. .
Free article

Abstract

Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism.

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Conflict of interest statement

Declaration of interests L.G. is/has been holding research contracts with Lytix Biopharma, Promontory, and Onxeo; has received consulting/advisory honoraria from Boehringer Ingelheim, AstraZeneca, OmniSEQ, Onxeo, The Longevity Labs, Inzen, Imvax, Sotio, Promontory, Noxopharm, EduCom, and the Luke Heller TECPR2 Foundation; and holds Promontory stock options. All other authors have no conflicts to declare.

Comment on

  • Manipulating mitochondrial electron flow enhances tumor immunogenicity.
    Mangalhara KC, Varanasi SK, Johnson MA, Burns MJ, Rojas GR, Esparza Moltó PB, Sainz AG, Tadepalle N, Abbott KL, Mendiratta G, Chen D, Farsakoglu Y, Kunchok T, Hoffmann FA, Parisi B, Rincon M, Vander Heiden MG, Bosenberg M, Hargreaves DC, Kaech SM, Shadel GS. Mangalhara KC, et al. Science. 2023 Sep 22;381(6664):1316-1323. doi: 10.1126/science.abq1053. Epub 2023 Sep 21. Science. 2023. PMID: 37733872 Free PMC article.

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