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Review
. 2023 Sep 26;13(10):1446.
doi: 10.3390/biom13101446.

The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer's Disease

Václav Trojan  1 , Leoš Landa  1   2 , Alexandra Šulcová  1 , Jiří Slíva  3 , Radovan Hřib  1   4
Affiliations
Review

The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer's Disease

Václav Trojan et al. Biomolecules. .

Abstract

The use of cannabinoids (substances contained specifically in hemp plants) for therapeutic purposes has received increased attention in recent years. Presently, attention is paid to two main cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). With respect to the psychotropic effects and dependence potential of THC (though it is very mild), its use is associated with certain restrictions, and thus the therapeutic properties of CBD are frequently emphasized because there are no limitations associated with the risk of dependence. Therefore, this review covers the main pharmacodynamic and pharmacokinetic features of CBD (including characteristics of endocannabinoidome) with respect to its possible beneficial effects on selected diseases in clinical practice. A substantial part of the text deals with the main effects of CBD on aging, including Alzheimer's disease and related underlying mechanisms.

Keywords: Alzheimer’s disease; aging; cannabidiol; cannabinoids.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Major substances and structures influenced by CBD.
Figure 2
Figure 2
The most promising treatment indications of CBD.
See this image and copyright information in PMC

References

    1. Kirkwood T.B.L. Understanding the Odd Science of Aging. Cell. 2005;120:437–447. doi: 10.1016/j.cell.2005.01.027. - DOI - PubMed
    1. Di Marzo V., Wang J., editors. The Endocannabinoidome: The World of Endocannabinoids and Related Mediators. 1st ed. Academic Press; Cambridge, MA, USA: 2014.
    1. Piomelli D. The molecular logic of endocannabinoid signalling. Nat. Rev. Neurosci. 2003;4:873–884. doi: 10.1038/nrn1247. - DOI - PubMed
    1. Di Marzo V., Piscitelli F. The Endocannabinoid System and its Modulation by Phytocannabinoids. Neurotherapeutics. 2015;12:692–698. doi: 10.1007/s13311-015-0374-6. - DOI - PMC - PubMed
    1. Pertwee R.G. Handbook of Experimental Pharmacology. Volume 168. Springer; Berlin/Heidelberg, Germany: 2005. Pharmacological actions of cannabinoids; pp. 1–51. - DOI - PubMed

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