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. 2023 Sep 26;13(10):1447.
doi: 10.3390/biom13101447.

Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia

Zainab Abdulameer Jasim  1 , Hussein Kadhem Al-Hakeim  2 , Samaneh Zolghadri  3 , Agata Stanek  4
Affiliations

Maternal Tryptophan Catabolites and Insulin Resistance Parameters in Preeclampsia

Zainab Abdulameer Jasim et al. Biomolecules. .

Abstract

Preeclampsia (PE) is a pregnancy-related disorder characterized by high blood pressure and proteinuria in the third trimester. The disease is associated with many metabolic and biochemical changes. There is a need for new biomarkers for diagnosis and follow-up. The present study examined the diagnostic ability of tryptophan catabolites (TRYCATs) and insulin resistance (IR) parameters in women with PE. This case-control study recruited sixty women with preeclampsia and 60 healthy pregnant women as a control group. Serum levels of TRYCATs (tryptophan, kynurenic acid, kynurenine, and 3-hydroxykynurenine) and IR parameters (insulin and glucose) were measured by ELISA and spectrophotometric methods. The results showed that PE women have a significantly lower tryptophan level than healthy pregnant women. However, there was a significant increase in kynurenic acid, kynurenic acid/kynurenine, kynurenine/tryptophan, and 3-hydroxykynurenine levels. PE women also have a state of IR. The correlation study indicated various correlations of IR and TRYCATs with clinical data and between each other, reflecting the role of these parameters in the pathophysiology of PE. The ROC study showed that the presence of IR state, reduced tryptophan, and increased 3-HK predicted PE disease in a suspected woman with moderate sensitivities and specificities. In conclusion, the pathophysiology of PE involves a state of IR and an alteration of the TRYCAT system. These changes should be taken into consideration when PE is diagnosed or treated.

Keywords: insulin resistance; kynurenic pathway; preeclampsia; tryptophan catabolites.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Receiver operating characteristic curves (ROC) of the insulin resistance parameters used for the diagnosis of PE.
Figure 2
Figure 2
ROC of the TRYCATs parameters used for the diagnosis of PE.
See this image and copyright information in PMC

References

    1. Banu S., Akhtary S., Pervin R. Obstetric Outcomes of Pregnant Women with Eclampsia: A study in a Tertiary Care Hospital. Sch. Int. J. Obs. Gynecol. 2022;5:147–150.
    1. Tossetta G., Fantone S., Balercia G., Ciavattini A., Giannubilo S.R., Marzioni D. Preeclampsia and severe acute respiratory syndrome coronavirus 2 infection: A systematic review. J. Hypertens. 2022;40:1629–1638. doi: 10.1097/HJH.0000000000003213. - DOI - PMC - PubMed
    1. Tanner M.S., Davey M.-A., Mol B.W., Rolnik D.L. The evolution of the diagnostic criteria of preeclampsia-eclampsia. Am. J. Obstet. Gynecol. 2022;226:S835–S843. doi: 10.1016/j.ajog.2021.11.1371. - DOI - PubMed
    1. Phipps E., Prasanna D., Brima W., Jim B. Preeclampsia: Updates in Pathogenesis, Definitions, and Guidelines. Clin. J. Am. Soc. Nephrol. 2016;11:1102–1113. doi: 10.2215/CJN.12081115. - DOI - PMC - PubMed
    1. Tsigas E.Z. The Preeclampsia Foundation: The voice and views of the patient and her family. Am. J. Obstet. Gynecol. 2022;226:S1254–S1264.e1251. doi: 10.1016/j.ajog.2020.10.053. - DOI - PubMed