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. 1986 Nov;35(6):1110-6.
doi: 10.4269/ajtmh.1986.35.1110.

Leishmania major: antileishmanial activity of methylbenzethonium chloride

J El-On, G Messer

Leishmania major: antileishmanial activity of methylbenzethonium chloride

J El-On et al. Am J Trop Med Hyg. 1986 Nov.

Abstract

Methylbenzethonium chloride (MBCl) decreased the growth of Leishmania major promastigotes and amastigotes in vitro. This decrease occurred during 4 days of exposure to the drug at concentrations of 0.1 to 2.5 micrograms ml-1. MBCl at 2 micrograms ml-1 killed almost 100% of the free living promastigotes and 87% of amastigotes within 4 days of treatment. Electron microscopy studies showed marked swelling of mitochondria in treated parasites. A possible additional effect on the parasite surface membrane is discussed.

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