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Review
. 2023 Sep 26;11(10):2638.
doi: 10.3390/biomedicines11102638.

Gut Microbiota Alteration and Its Modulation with Probiotics in Celiac Disease

Angela Saviano  1 , Carmine Petruzziello  2 , Mattia Brigida  3 , Maria Rita Morabito Loprete  1 , Gabriele Savioli  4 , Alessio Migneco  1 , Veronica Ojetti  5
Affiliations
Review

Gut Microbiota Alteration and Its Modulation with Probiotics in Celiac Disease

Angela Saviano et al. Biomedicines. .

Abstract

Celiac disease (CD) is a chronic inflammation of the small intestine triggered by gluten ingestion in genetically predisposed people. Recent literature studies highlight the possible role of the gut microbiota in the pathogenesis of this disease. The gut microbiota is a complex community of microorganisms that can interact with the innate and adaptative immune systems. A condition of dysbiosis, which refers to an alteration in the composition and function of the human gut microbiota, can lead to a dysregulated immune response. This condition may contribute to triggering gluten intolerance, favoring the development and/or progression of CD in genetically susceptible patients. Interestingly, studies on children and adults with CD showed a different microbiome profile in fecal samples, with a different degree of "activity" for the disease. From this point of view, our review aimed to collect and discuss modern evidence about the alteration of the gut microbiota and its modulation with probiotics, with possible future indications in the management of patients affected by CD.

Keywords: celiac disease; diet; gluten; gut microbiota; immune system; probiotics.

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Conflict of interest statement

All the authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the potential benefits of probiotic use in patients affected by celiac disease.
See this image and copyright information in PMC

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