Androgen Receptor Signaling in Prostate Cancer Genomic Subtypes

Mohamed Ali Hussein^{1

2}, Gnanasekar Munirathinam³

Affiliations

¹ Department of Pharmaceutical Services, Children's Cancer Hospital Egypt, Cairo 57357, Egypt.
² Department of Biology, School of Sciences and Engineering, American University in Cairo, New Cairo 11835, Egypt.
³ Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, IL 61107, USA.

Editorial

Mohamed Ali Hussein et al. Cancers (Basel). 2023.

. 2023 Oct 13;15(20):4969.

doi: 10.3390/cancers15204969.

Mohamed Ali Hussein^{1

2}, Gnanasekar Munirathinam³

¹ Department of Pharmaceutical Services, Children's Cancer Hospital Egypt, Cairo 57357, Egypt.
² Department of Biology, School of Sciences and Engineering, American University in Cairo, New Cairo 11835, Egypt.
³ Department of Biomedical Sciences, College of Medicine, University of Illinois, Rockford, IL 61107, USA.

Abstract

Prostate cancer (PCa) constitutes a significant cause of mortality, with over 37,000 new deaths each year [...].

The authors declare no conflict of interest.

1. Siegel R.L., Miller K.D., Wagle N.S., Jemal A. Cancer statistics, 2023. CA Cancer J. Clin. 2023;73:17–48. doi: 10.3322/caac.21763. - DOI - PubMed
1. Van-Duyne G., Blair I.A., Sprenger C., Moiseenkova-Bell V., Plymate S., Penning T.M. The androgen receptor. Vitam. Horm. 2023;123:439–481. doi: 10.1016/bs.vh.2023.01.001. - DOI - PubMed
1. Messner E.A., Steele T.M., Tsamouri M.M., Hejazi N., Gao A.C., Mudryj M., Ghosh P.M. The Androgen Receptor in Prostate Cancer: Effect of Structure, Ligands and Spliced Variants on Therapy. Biomedicines. 2020;8:422. doi: 10.3390/biomedicines8100422. - DOI - PMC - PubMed
1. Shafi A.A., Yen A.E., Weigel N.L. Androgen receptors in hormone-dependent and castration-resistant prostate cancer. Pharmacol. Ther. 2013;140:223–238. doi: 10.1016/j.pharmthera.2013.07.003. - DOI - PubMed
1. Watson P.A., Arora V.K., Sawyers C.L. Emerging mechanisms of resistance to androgen receptor inhibitors in prostate cancer. Nat. Rev. Cancer. 2015;15:701–711. doi: 10.1038/nrc4016. - DOI - PMC - PubMed