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. 2023 Sep 23;14(10):1853.
doi: 10.3390/genes14101853.

High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

Daniel Uricoechea Patiño  1 , Andrew Collins  2 , Oscar Julián Romero García  3 , Gustavo Santos Vecino  4 , José Vicente Rodríguez Cuenca  5 , Jaime E Bernal  6 , Escilda Benavides Benítez  6 , Saray Vergara Muñoz  6 , Ignacio Briceño Balcázar  1
Affiliations

High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

Daniel Uricoechea Patiño et al. Genes (Basel). .

Abstract

The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.

Keywords: Colombia; ancient DNA; mtDNA HVS-I; native American ancestries; native American founding lineages; native American genetic history; pre-Hispanic.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Displays the geographical distribution of ancient skeletal remains from a historical Colombian population. The figure provides information about the respective excavation sites, estimated dates, and the total number of samples that were comprehensively examined.
Figure 2
Figure 2
Depicts the phylogenetic tree with samples classified into haplogroups and haplotypes. All the sorted samples are amalgamated into a comprehensive tree encompassing all rCRS-related polymorphisms. Private polymorphisms known by Phylotree are indicated in green. The individuals are denoted in purple. Constructed through the neighbor joining algorithm based on Phylotree, the phylogenetic tree’s sample names have been abbreviated for clarity.
See this image and copyright information in PMC

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