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. 2023 Oct 15;14(10):1941.
doi: 10.3390/genes14101941.

Genomic Scanning of Inbreeding Depression for Litter Size in Two Varieties of Iberian Pigs

Carlos Hervás-Rivero  1 , Houssemeddine Srihi  1 , David López-Carbonell  1 , Joaquim Casellas  2 , Noelia Ibáñez-Escriche  3 , Sara Negro  4 , Luis Varona  1
Affiliations

Genomic Scanning of Inbreeding Depression for Litter Size in Two Varieties of Iberian Pigs

Carlos Hervás-Rivero et al. Genes (Basel). .

Abstract

Inbreeding depression is expected to be more pronounced in fitness-related traits, such as pig litter size. Recent studies have suggested that the genetic determinism of inbreeding depression may be heterogeneous across the genome. Therefore, the objective of this study was to conduct a genomic scan of the whole pig autosomal genome to detect the genomic regions that control inbreeding depression for litter size in two varieties of Iberian pigs (Entrepelado and Retinto). The datasets consisted of 2069 (338 sows) and 2028 (327 sows) records of litter size (Total Number Born and Number Born Alive) for the Entrepelado and Retinto varieties. All sows were genotyped using the Geneseek GGP PorcineHD 70 K chip. We employed the Unfavorable Haplotype Finder software to extract runs of homozygosity (ROHs) and conducted a mixed-model analysis to identify highly significant differences between homozygous and heterozygous sows for each specific ROH. A total of eight genomic regions located on SSC2, SSC5, SSC7, SSC8, and SSC13 were significantly associated with inbreeding depression, housing some relevant genes such as FSHR, LHCGR, CORIN, AQP6, and CEP120.

Keywords: Iberian pig; inbreeding depression; litter size.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Distribution of the ROH sizes (according to SNP number) in the Entrepelado (EE) and Retinto (RR) populations.
Figure 2
Figure 2
Distribution of the ROH sizes (according to base pairs) in the Entrepelado (EE) and Retinto (RR) populations.
Figure 3
Figure 3
Distribution of the estimates of effects associated with the presence or absence of ROH for TNB (Total Number Born) and NBA (Number Born Alive) in Entrepelado and Retinto. Red lines represent the average effect of the ROH on TNB and NBA.
Figure 4
Figure 4
Distribution of ROHs with p-values lower than 0.05, 0.01 and 0.001 in Entrepelado (EE) population for (A) Total Number Born (TNB) and (B) Number Born Alive (NBA).
Figure 5
Figure 5
Distribution of ROHs with p-values lower than 0.05, 0.01 and 0.001 in Retinto (RR) population for (A) Total Number Born (TNB) and (B) Number Born Alive (NBA).
See this image and copyright information in PMC

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