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Review
. 2023 Sep 22;13(10):1947.
doi: 10.3390/life13101947.

Update on Obesity in Psoriasis Patients

Dan Vata  1   2 , Bogdan Marian Tarcau  1   2 , Ioana Adriana Popescu  1   2 , Ioana Alina Halip  1   2 , Adriana Ionela Patrascu  1   2 , Dragos-Florin Gheuca Solovastru  3 , Madalina Mocanu  1   2 , Petronela Cristina Chiriac  4 , Laura Gheuca Solovastru  1   2
Affiliations
Review

Update on Obesity in Psoriasis Patients

Dan Vata et al. Life (Basel). .

Abstract

Psoriasis is a chronic inflammatory skin condition, with genetic, epigenetic, environmental, and lifestyle factors contributing to its onset and recurrence. Severe psoriasis has a great impact on quality of life, which is similar to that of insulin-dependent diabetes, depression, and ischemic heart disease, but with a lower mortality. There is an overlap between the rising incidences of autoimmune diseases and obesity. In recent years, research has shown that there is an association between psoriasis and obesity. Psoriasis is linked to obesity in a two-way manner, as each can precipitate the development of the other. Several adipose tissue-secreted adipokines were shown to be elevated in obese psoriasis patients, exhibiting similar mechanisms of action to those underlying the pathogenesis of psoriasis. Excess body weight can influence not only the treatment response in psoriasis, but also the adverse events, leading to decreased patient compliance. Specific human microbiome patterns have been identified for obesity and psoriasis and could represent a future therapeutic target in selected individuals.

Keywords: adipokines; autoimmune; microbiome; obesity; psoriasis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the bidirectional link between psoriasis and obesity.
See this image and copyright information in PMC

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