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. 2023 Oct 19;13(10):2082.
doi: 10.3390/life13102082.

Maternal and Newborn Characteristics-A Comparison between Healthy and Thrombophilic Pregnancy

Miruna Samfireag  1   2 , Ovidiu Potre  3 , Cristina Potre  3 , Radu-Dumitru Moleriu  4   5 , Izabella Petre  6 , Ema Borsi  3 , Teodora Hoinoiu  1   2 , Ion Petre  4 , Tudor-Alexandru Popoiu  4 , Stela Iurciuc  7 , Andrei Anghel  8
Affiliations

Maternal and Newborn Characteristics-A Comparison between Healthy and Thrombophilic Pregnancy

Miruna Samfireag et al. Life (Basel). .

Abstract

A thrombophilic woman is more likely to experience difficulties during pregnancy, difficulties that will also affect the development of the newborn. This study aims to compare maternal and newborn characteristics between healthy and thrombophilic pregnancy. The following characteristics were analysed: maternal characteristics (BMI- body mass index, haemostasis parameters, thrombophilia-specific treatment) and newborn characteristics (gestational period, birth weight, the Apgar score). This follow-up study spanning five years, from 2018 to 2022, focuses on a cohort of 500 women who underwent delivery hospitalization in the western region of Romania. The maternal characteristics influence the newborn: the greater the weight of the mother with thrombophilia, the more the chances that the fetus will have a lower birth weight; increasing the dose of LMWH (low molecular weight heparin), connected with the necessity to control the homeostasis parameters, the more likely the fetus will be born with a lower birth weight. A pregnant woman with thrombophilia, treated appropriately, having a normal weight, and not presenting other risk factors independent of thrombophilia, will have a newborn with characteristics similar to a healthy pregnant woman.

Keywords: newborn; pregnancy; thrombophilia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The data distribution of the numerical data, split into the four studied groups.
Figure 1
Figure 1
The data distribution of the numerical data, split into the four studied groups.
Figure 1
Figure 1
The data distribution of the numerical data, split into the four studied groups.
Figure 2
Figure 2
The data dynamics resulted from the Kruskal—Wallis test upon the studied groups for maternal BMI in the first and last trimester, newborn weight, gestational period, and APGAR score. The statistical significance is written below each chart.
Figure 3
Figure 3
The data distribution was obtained from the Wilcoxon Signed Rank test.
Figure 3
Figure 3
The data distribution was obtained from the Wilcoxon Signed Rank test.
Figure 4
Figure 4
The data distribution for the coagulation parameters (PT, INR, APTT, and Fibrinogen) was obtained from the Friedman test in all three time moments, for all types of thrombophilia, as well as the statistical significance of each case.
Figure 4
Figure 4
The data distribution for the coagulation parameters (PT, INR, APTT, and Fibrinogen) was obtained from the Friedman test in all three time moments, for all types of thrombophilia, as well as the statistical significance of each case.
Figure 5
Figure 5
The dose distribution of LMWH (ml), obtained from the Friedman test during pregnancy, for all types of thrombophilia, as well as the statistical significance of each case.
Figure 5
Figure 5
The dose distribution of LMWH (ml), obtained from the Friedman test during pregnancy, for all types of thrombophilia, as well as the statistical significance of each case.
Figure 6
Figure 6
The regression model presenting the dependence between the dose of LMWH and the newborn weight, using a scatter plot chart r=−0.63; R2=39.69, p<0.001.
Figure 7
Figure 7
The regression model presents the dependence between the dose of LMWH (ml) and the anti-Factor Xa levels in all three samples.
Figure 7
Figure 7
The regression model presents the dependence between the dose of LMWH (ml) and the anti-Factor Xa levels in all three samples.
See this image and copyright information in PMC

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