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Randomized Controlled Trial
. 2023 Dec:117:105901.
doi: 10.1016/j.parkreldis.2023.105901. Epub 2023 Oct 21.

Effects of high-intensity interval training and moderate-intensity continuous training on sarcopenia-related parameters in participants with Parkinson's disease: A 24-week randomized pilot trial substudy

Ryul Kim  1 , Seohee Choi  2 , Nyeonju Kang  3 , Kiwon Park  4 , Heehyun Shin  3 , Hanall Lee  3 , Hyungwoo Lee  3 , Jin-Sun Jun  5 , Beomseok Jeon  6 , Kyeongho Byun  7
Affiliations
Randomized Controlled Trial

Effects of high-intensity interval training and moderate-intensity continuous training on sarcopenia-related parameters in participants with Parkinson's disease: A 24-week randomized pilot trial substudy

Ryul Kim et al. Parkinsonism Relat Disord. 2023 Dec.

Abstract

Objective: To evaluate the potential efficacy of two different supervised exercise regimens, namely high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), on sarcopenia-related parameters in participants with Parkinson's disease (PD).

Methods: We analyzed data from a randomized controlled pilot trial (CRIS identifier: KCT0007130). An aerobic exercise intervention using a cycle ergometer (40-60 min) in combination with calisthenics (5 min) was performed in three sessions/week for 24 weeks for HIIT (60% maximum aerobic power for 30-50 s with 1-min rest intervals) and MICT (50% peak oxygen consumption) groups. Changes in sarcopenia-related parameters, including appendicular skeletal muscle mass (ASM), ASM index (ASM/height2), handgrip strength, 6-min walking distance, and 30-s chair-stand test (30CST) score, were compared among the HIIT (n = 9), MICT (n = 10), and usual care (n = 11) groups.

Results: The HIIT group showed greater increases in leg lean mass (p = 0.011), ASM (p = 0.035), and ASM index (p = 0.025), and greater improvements in 6-min walking distance (p = 0.024) and 30CST scores (p = 0.026) compared with the usual care group. However, among these parameters, only the 30CST score significantly improved in the MICT group compared to the usual care group (p = 0.002). Three of the four (75%) sarcopenic patients who underwent HIIT showed improved sarcopenia after the 24-week exercise intervention, whereas it did not improve in the sarcopenic patients included in the MICT (n = 2) and usual care (n = 2) groups.

Conclusion: This study suggests that HIIT may be superior to MICT in improving sarcopenia in patients with PD. Further large-scale investigations are required to confirm our findings.

Keywords: Exercise; Intensity; Muscle mass; Parkinson's disease; Sarcopenia.

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Conflict of interest statement

Declaration of competing interest The authors have no conflicts of interest.

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