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. 1979 Aug;139(2):701-4.
doi: 10.1128/jb.139.2.701-704.1979.

Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli

J J Dermody, G T Robinson, R Sternglanz

Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli

J J Dermody et al. J Bacteriol. 1979 Aug.

Abstract

A new Escherichia coli deoxyribonucleic acid (DNA) ligase mutant has been identified among a collection of temperature-sensitive DNA replication mutants isolated recently (Sevastopoulos, Wehr, and Glaser, Proc. Natl. Acad. Sci. U.S.A. 74:3485-3489, 1977). At the nonpermissive temperature DNA synthesis in the mutant stops rapidly, the DNA is degraded to acid-soluble material, and cell death ensures. This suggests that the mutant may be among the most ligase-deficient strains yet characterized.

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References

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    1. Proc Natl Acad Sci U S A. 1971 May;68(5):1002-5 - PubMed
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