Advancing with cancer immunotherapeutics: CD29⁺ regulatory T cell antagonism

Francisco Javier Cubero^{1

2}, Pablo Sarobe^{3

4

5}, Gisa Tiegs⁶

Affiliations

¹ Immunology, Ophthalmology and ENT, Complutense University of Madrid Faculty of Medicine, Madrid, Spain.
² Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
³ Centre for Biomedical Research, Network on Liver and Digestive Diseases(CIBEREHD), Madrid, Spain.
⁴ Programa de Inmunología e Inmunoterapia, Centro de Investigación MédicaAplicada (CIMA, CCUN), Universidad de Navarra, Pamplona, Spain.
⁵ IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
⁶ Insitute of Experimental Immunology and Hepatology, University Medical Center, Hamburg, Germany g.tiegs@uke.de.

Comment

Francisco Javier Cubero et al. Gut. 2024.

. 2024 Feb 23;73(3):391-392.

doi: 10.1136/gutjnl-2023-331048.

Francisco Javier Cubero^{1

2}, Pablo Sarobe^{3

4

5}, Gisa Tiegs⁶

¹ Immunology, Ophthalmology and ENT, Complutense University of Madrid Faculty of Medicine, Madrid, Spain.
² Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
³ Centre for Biomedical Research, Network on Liver and Digestive Diseases(CIBEREHD), Madrid, Spain.
⁴ Programa de Inmunología e Inmunoterapia, Centro de Investigación MédicaAplicada (CIMA, CCUN), Universidad de Navarra, Pamplona, Spain.
⁵ IdiSNA, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
⁶ Insitute of Experimental Immunology and Hepatology, University Medical Center, Hamburg, Germany g.tiegs@uke.de.

No abstract available

Keywords: HEPATOCELLULAR CARCINOMA; IMMUNOTHERAPY; INTEGRINS; LIVER; T LYMPHOCYTES.

Conflict of interest statement

Competing interests: None declared.

Immunosuppressive CD29⁺ Treg accumulation in the liver in mice on checkpoint inhibitor therapy.
Green BL, Myojin Y, Ma C, Ruf B, Ma L, Zhang Q, Rosato U, Qi J, Revsine M, Wabitsch S, Bauer K, Benmebarek MR, McCallen J, Nur A, Wang X, Sehra V, Gupta R, Claassen M, Wang XW, Korangy F, Greten TF. Green BL, et al. Gut. 2024 Feb 23;73(3):509-520. doi: 10.1136/gutjnl-2023-330024. Gut. 2024. PMID: 37770128 Free PMC article.