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Review
. 2023;64(9):1066-1073.
doi: 10.11406/rinketsu.64.1066.

[Updated treatment strategy for transplant-eligible multiple myeloma: current status and future perspectives]

[Article in Japanese]
Nobuhiro Tsukada  1
Affiliations
Review

[Updated treatment strategy for transplant-eligible multiple myeloma: current status and future perspectives]

[Article in Japanese]
Nobuhiro Tsukada. Rinsho Ketsueki. 2023.

Abstract

Treatment outcomes of multiple myeloma (MM) have dramatically improved in the past 20 years. The IFM/DFCI group reported that triplet induction (bortezomib, lenalidomide, and dexamethasone), followed by up-front high-dose melphalan and autologous stem cell transplantation (HDM/ASCT) and maintenance therapy, demonstrated a median progression-free survival (PFS) of 50 months. Therefore, up-front HDM/ASCT is considered standard care even in the era of novel agents. Daratumumab, lenalidomide, and dexamethasone have also been reported to prolong PFS for newly diagnosed transplant-ineligible MM. Quadruplet induction, including anti-CD38 antibody, will be approved even for transplant-eligible MM soon. Conversely, the success of chimeric antigen receptor T-cell therapy revealed that cellular immunotherapy may play an important role in treating MM. This review discussed the current standard of care and future perspectives for transplant-eligible MM.

Keywords: HDM/ASCT BCMA; Multiple myeloma.

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