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Randomized Controlled Trial
. 2023 Oct 29;23(1):821.
doi: 10.1186/s12903-023-03530-w.

Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on early bone healing after endodontic microsurgery: a randomized controlled trial

Jae-Seek You  1 , Gyeo-Woon Jung  1 , Ji-Su Oh  1 , Seong-Yong Moon  1 , Won-Pyo Lee  2 , Hyoung-Hoon Jo  3
Affiliations
Randomized Controlled Trial

Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on early bone healing after endodontic microsurgery: a randomized controlled trial

Jae-Seek You et al. BMC Oral Health. .

Abstract

Background: This randomized controlled clinical trial compared the effects of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on early bone healing after endodontic microsurgery.

Methods: Eighteen patients with an isolated periapical lesion < 10 mm in the maxillary anterior region were randomly assigned to three groups: control, PRF, or CGF. Endodontic microsurgery was performed and PRF or CGF membranes were placed over the bone defects in the experimental groups. The volume of the bone defect at postoperative one week, three months, and six months was evaluated using cone-beam computed tomography and Mimics software. The results were statistically analyzed using the Kruskal-Wallis test and post-hoc Mann-Whitney U test with Bonferroni correction.

Results: At the three-month follow-up, the PRF and CGF groups showed significantly greater bone healing compared with the control group (p > 0.05). However, no significant difference was observed between the PRF and CGF groups. At the six-month follow-up, no significant differences were observed between the groups.

Conclusions: These results suggested that PRF and CGF promote early bone healing after endodontic microsurgery.

Keywords: Bone defect; Concentrated growth factor; Cone-beam computed tomography; Endodontic microsurgery; Platelet-rich fibrin.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of participants through each stage of the trial
Fig. 2
Fig. 2
Preparation of platelet-rich fibrin and concentrated growth factor
Fig. 3
Fig. 3
Surgical procedure A Preoperative photograph B Submarginal incision and full thickness periosteal flap C Labial bone osteotomy D Curettage and root-end resection E Resected surface with methylene blue stain (X20) F Retrograde filling (X20) G without membrane (control group) H platelet-rich fibrin or concentrated growth factor membrane placed over bone defect. I Postoperative photograph
Fig. 4
Fig. 4
Measurement of the bone-defect volume using Mimics medical software
Fig. 5
Fig. 5
Representative sagittal cone-beam computed tomography and 3D images of the bone defect. A, D one week after surgery B, E Three months after surgery C, F Six months after surgery
See this image and copyright information in PMC

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