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Case Reports
. 2023 Oct;51(10):3000605231206958.
doi: 10.1177/03000605231206958.

Duodenal stenosis caused by locally advanced upper tract urothelial carcinoma: a case report

Jun Lu  1 , Weijiang Zhou  1 , Huadong He  2 , Jun Chen  1 , Jian Wu  3 , Lixin Zhou  1 , Xiao Xu  1   4
Affiliations
Case Reports

Duodenal stenosis caused by locally advanced upper tract urothelial carcinoma: a case report

Jun Lu et al. J Int Med Res. 2023 Oct.

Abstract

Duodenal stenosis caused by upper tract urothelial carcinoma (UTUC) is rare. A 70-year-old male patient was diagnosed with a UTUC invading the duodenum 3 months before admission. Owing to duodenal stenosis, enteral nutrition was necessary. We performed pancreaticoduodenectomy with right nephroureterectomy and right hemicolectomy using a multi-disciplinary approach. Postoperative pathology revealed a UTUC invading the right kidney, duodenum, pancreas, and transverse colon. The patient underwent chemotherapy and immunotherapy after surgery, which improved his quality of life.

Keywords: Case report; chemotherapy; duodenal stenosis; immunotherapy; invasion; multidisciplinary discussion; surgery; upper tract urothelial carcinoma.

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Conflict of interest statement

Declaration of conflicting interestThe authors declare that there is no conflict of interest.

Figures

Figure 1.
Figure 1.
(a) The tumor caused right ureteral stenosis and renal pelvis dilation and invaded the duodenum (red arrows) and (b) Surgical specimen: the tumor is outlined by the circle.
Figure 2.
Figure 2.
Histopathology (HE staining) showing a high-grade infiltrating urothelial carcinoma of the right ureter with extensive scaling and necrosis (a, red arrow; ×200). Immunohistochemical staining is positive for GATA3 (b, red arrow) and P63 (c, red arrow; ×200). HE, hematoxylin and eosin; GATA 3, GATA binding protein 3; P63, tumor protein 63.
See this image and copyright information in PMC

References

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Publication types

Supplementary concepts