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. 2023 Oct;52(10):2099-2108.
doi: 10.18502/ijph.v52i10.13848.

Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis

Yanpeng Wang  1 , Yinzhen Zhang  1 , Changwei Zhao  2 , Wenjun Cai  3 , Zhengyan Wang  1 , Wenhai Zhao  2
Affiliations

Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis

Yanpeng Wang et al. Iran J Public Health. 2023 Oct.

Abstract

Background: Sedentary behavior and physical activity are still ambiguous in their effects on osteoarthritis. We aimed to evaluate the effects of physical activity and sedentary behavior on osteoarthritis to provide a reference for the prevention of osteoarthritis.

Methods: This study was conducted in Changchun, China in 2022. We used two-sample Mendelian randomization with the SNP as an instrumental variable to investigate the effect of physical activity and sedentary behavior on osteoarthritis. In addition, a two-step Mendelian randomization method was used to test whether mediating factors (BMI, smoking, Apolipoprotein B) were involved in mediating the effects of exposure factors on osteoarthritis.

Results: TV watching was causally related to knee osteoarthritis and spine osteoarthritis, and they were positively correlated (knee osteoarthritis: OR=1.162,95 %CI: 1.027-1.315, P=0.017; spine osteoarthritis: OR=1.208,95 %CI: 1.033-1.413, P=0.018). BMI played a mediating role in the process of TV watching with knee osteoarthritis and spine osteoarthritis. ((The proportion of BMI mediating effect: knee osteoarthritis: 47.1% (95% CI: 36.7%~63.2%); spine osteoarthritis: 29.5% (95% CI: 19.3%~40.8%)). The proportion of Smoking mediating effect in the process of TV watching with spine osteoarthritis was 16.1% (95% CI: 3.7% ~ 31.6%).

Conclusion: TV watching is a potential risk factor for osteoarthritis and plays a role through modifiable factors such as BMI and smoking, therefore, interventions on these factors have the potential to reduce the burden of osteoarthritis caused by longer TV watching times.

Keywords: Lifestyle; Mendelian randomization; Osteoarthritis; Sedentary behavior.

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Figures

Fig.1:
Fig.1:
Overview and assumptions of the Mendelian randomization study design
Fig. 2:
Fig. 2:
Flow chart about the analytical methods and how the MR analysis was performed step-by-step
Fig.3:
Fig.3:
Associations of genetically Physical Activity, Sedentary Behavior with Osteoarthritis using random effect inverse-variance weighted method. SNP, single nucleotide polymorphism;IVW, inverse-variance weighted; OR, odds ratio; CI,confidence interval
Fig.4:
Fig.4:
(a) MR-estimated effects of TV watching on each mediator separately, presented as β with 95% CI. (b) MR-estimated effects of each mediator separately on Osteoarthritis after MVMR adjustment for TV watching, presented as β with 95% CI. (c) MR-estimated proportions mediated (%) are presented with 95% CIs. OA, Osteoarthritis; TV, television; CI, confidence interval
See this image and copyright information in PMC

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