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Review
. 2023 Oct 23:29:e20230029.
doi: 10.1590/1678-9199-JVATITD-2023-0029. eCollection 2023.

Research advances in the degradation of aflatoxin by lactic acid bacteria

Yuxi Wang  1 , Lishi Jiang  1 , Ying Zhang  1 , Ran Ran  2 , Xiao Meng  1 , Shukun Liu  1
Affiliations
Review

Research advances in the degradation of aflatoxin by lactic acid bacteria

Yuxi Wang et al. J Venom Anim Toxins Incl Trop Dis. .

Abstract

Aflatoxins are toxic secondary metabolites that often contaminate food and animal feed, causing huge economic losses and serious health hazards. Aflatoxin contamination has become a major concern worldwide. Biological methods have been used to reduce aflatoxins in food and feed by inhibiting toxin production and detoxification. Among biological methods, lactic acid bacteria are of significant interest because of their safety, efficiency, and environmental friendliness. This study aimed to review the mechanisms by which lactic acid bacteria degrade aflatoxins and the factors that influence their degradation efficiency, including the action of the lactic acid bacteria themselves (cell wall adsorption) and the antifungal metabolites produced by the lactic acid bacteria. The current applications of lactic acid bacteria to food and feed were also reviewed. This comprehensive analysis provided insight into the binding mechanisms between lactic acid bacteria and aflatoxins, facilitating the practical applications of lactic acid bacteria to food and agriculture.

Keywords: Aflatoxins; applications; biodegradation; lactic acid bacteria; mechanism.

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Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.. Article selection flow chart.
Figure 2.
Figure 2.. Mechanism of action of lactic acid bacteria in the degradation of aflatoxins. The inhibition may be the effect of these mechanisms acting together.
Figure 3.
Figure 3.. Mechanism of AFs (exemplified by AFB1) adsorption by lactic acid bacteria cell walls. LAB can adsorb AFs via peptidoglycan, polysaccharide, and phosphate in the cell wall, and through hydrophobic and electrostatic interactions.
Figure 4.
Figure 4.. Antifungal metabolites produced by lactic acid bacteria.
See this image and copyright information in PMC

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