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Case Reports
. 2023 Oct 12:14:1272742.
doi: 10.3389/fimmu.2023.1272742. eCollection 2023.

Case Report: The many faces of bullous pemphigoid

Laura Rechtien  1   2 , Lukas Sollfrank  1   2 , Yannick Foerster  1   2 , Carola Berking  1   2 , Michael Sticherling  1   2
Affiliations
Case Reports

Case Report: The many faces of bullous pemphigoid

Laura Rechtien et al. Front Immunol. .

Abstract

The pemphigoid group comprises a number of bullous skin diseases with autoantibodies against different constituents of the basement membrane zone that result in subepidermal detachment and clinically characteristic tense blisters, erosions, urticarial erythema, and itching. Apart from the most frequent type of bullous pemphigoid with antibodies against BP180, which is found predominantly in elderly patients, the disease may present at other ages and different pathogenic conditions. Here, four cases are presented of young age (3 months and 25, 34, and 46 years) and in association with vaccination, pregnancy, or metastatic cancer. Though anti-BP180 was found in all cases, a different pathogenic background may be found in any of them, resulting in characteristic clinical manifestation, yet demanding specifically adapted therapeutic approaches.

Keywords: COVID-19 vaccination; bullous autoimmune disease; bullous pemphigoid; juvenile pemphigoid; pemphigoid gestationis.

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Conflict of interest statement

MS has performed clinical studies on bullous pemphigoid sponsored by Sanofi and Argenx. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Multiple erythematous, partly excoriated papules, blisters, and erosions disseminated on the entire skin.
Figure 2
Figure 2
Multiple blisters, wheals, and erosions on the trunk and extremities.
Figure 3
Figure 3
Widespread urticarial skin lesions on the trunk including the periumbilical region.
Figure 4
Figure 4
Multiple wheals and small erosions on the trunk and extremities.
See this image and copyright information in PMC

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