Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2023 Oct 24:15:1611-1619.
doi: 10.2147/IJWH.S418135. eCollection 2023.

Case Series and a Literature Review: Two Ovarian Clear Cell Carcinoma Cases with Recurrent Endometriosis

Dan Yin  1 , Yan-Jiao Jiang  2
Affiliations
Case Reports

Case Series and a Literature Review: Two Ovarian Clear Cell Carcinoma Cases with Recurrent Endometriosis

Dan Yin et al. Int J Womens Health. .

Abstract

Introduction: Endometriosis-associated ovarian cancer (EAOC) is rare, occurring approximately in 1% of women with ovarian endometriosis. The main histological types are endometrioid adenocarcinoma and clear cell carcinoma (CCC), with the latter being the least common.

Case presentation: In our hospital, we recently summarized two patients with ovarian clear cell carcinoma with similar characteristics. They all had endometriosis for a long time and had undergone ovarian cyst removal due to a chocolate cyst. Unfortunately, the cyst recurred after surgery, and the histological diagnosis was clear cell carcinoma. In case 1, the expression of P53 was found in the tumor by regular examination, and the stage was IIB. In Case 2, we found it in intraoperative freezing; the stage was IA. Case 1 has been treated with the TP regimen six times, and the survival period has reached one year. Case 2 had a survival period of 6 years after completing six TP regimen treatments. Clinicians should pay attention to patients with a long history of endometriosis and postoperative recurrence of ovarian cysts accompanied by serum CA-125 of more than 200U/mL. Imaging examination has a good prospect in diagnosing malignant transformation of endometriosis, especially PET-CT.

Conclusion: This case report highlights the risk factors related to the formation of ovarian clear cell carcinoma and suggests that the follow-up of patients with ovarian endometriosis is essential because of its recurrence characteristics. Radical surgery and postoperative platinum-containing chemotherapy are the primary treatment methods at present.

Keywords: case report; endometriosis; gynecological tumor; malignant transformation; ovarian clear cell carcinoma.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

None
Graphical abstract
Figure 1
Figure 1
PET-CT (Case 1) A pelvic cystic-solid mass was considered to originate from right ovarian cystadenocarcinoma.
Figure 2
Figure 2
Pathology (hematoxylin and eosin staining).
Figure 3
Figure 3
Timeline of the case presentation with relevant data.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Mikhaleva LM, Davydov AI, Patsap OI, et al. Malignant transformation and associated biomarkers of ovarian endometriosis: a narrative review. Adv Ther. 2020;37(6):2580–2603. doi:10.1007/s12325-020-01363-5 - DOI - PMC - PubMed
    1. Li B, Wang Y, Wang Y, et al. Deep infiltrating endometriosis malignant invasion of cervical wall and rectal wall with lynch syndrome: a rare case report and review of literature. Front Oncol. 2022;12:832228. doi:10.3389/fonc.2022.832228 - DOI - PMC - PubMed
    1. Matalliotakis M, Matalliotaki C, Trivli A, et al. Keeping an eye on perimenopausal and postmenopausal endometriosis. Diseases. 2019;7(29):1–7. doi:10.3390/diseases7010029 - DOI - PMC - PubMed
    1. Marie-Scemama L, Even M, Joliniere JBDL, et al. Endometriosis and the menopause: why the question merits our full attention. Horm Mol Biol Clin Investig. 2019;37(2):20180071. doi:10.1515/hmbci-2018-0071 - DOI - PubMed
    1. Murakami K, Kotani Y, Shiro R, et al. Endometriosis-associated ovarian cancer occurs early during follow-up of endometrial cysts. Int J Clin Oncol. 2020;25:51–58. doi:10.1007/s10147-019-01536-5 - DOI - PubMed

Publication types