A Salt in the Buffer Zone: Potassium Dysregulation Drives Glioma Growth?

Affiliations

Comment

James S Street et al. Epilepsy Curr. 2023.

. 2023 Aug 8;23(5):309-311.

doi: 10.1177/15357597231193318. eCollection 2023 Sep-Oct.

¹ Department of Clinical and Experimental Epilepsy, University College London Queen Square Institute of Neurology.

No abstract available

Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation.
Curry RN, Aiba I, Meyer J, Lozzi B, Ko Y, McDonald MF, Rosenbaum A, Cervantes A, Huang-Hobbs E, Cocito C, Greenfield JP, Jalali A, Gavvala J, Mohila C, Serin Harmanci A, Noebels J, Rao G, Deneen B. Curry RN, et al. Neuron. 2023 Mar 1;111(5):682-695.e9. doi: 10.1016/j.neuron.2023.01.013. Epub 2023 Feb 13. Neuron. 2023. PMID: 36787748 Free PMC article.

1. Schaff LR, Mellinghoff IK. Glioblastoma and other primary brain malignancies in adults: a review. JAMA. 2023;329(7):574–587. doi:10.1001/jama.2023.0023 - PMC - PubMed
1. Curry RN, Aiba I, Meyer J, et al. Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation. Neuron. 2023;111(5):682–695.e9. doi:10.1016/j.neuron.2023.01.013 - PMC - PubMed
1. Buckingham SC, Campbell SL, Haas BR, et al. Glutamate release by primary brain tumors induces epileptic activity. Nat Med. 2011;17(10):1269–1274. doi:10.1038/nm.2453 - PMC - PubMed
1. Campbell SL, Robel S, Cuddapah VA, et al. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia. 2015;63(1):23–36. doi:10.1002/glia.22730 - DOI - PMC - PubMed
1. Huang-Hobbs E, Cheng YT, Ko Y, et al. Remote neuronal activity drives glioma progression through SEMA4F [published online June 28, 2023]. Nature. doi:10.1038/s41586-023-06267-2 - PMC - PubMed