Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Oct 15;23(5):298-302.
doi: 10.1177/15357597231191887. eCollection 2023 Sep-Oct.

Mechanisms of Neurostimulation for Epilepsy

Affiliations

Mechanisms of Neurostimulation for Epilepsy

Sheela Toprani et al. Epilepsy Curr. .

Abstract

This review discusses the use of neurostimulation therapies for epilepsy treatment, including vagal nerve stimulation, responsive neurostimulation, and deep brain stimulation. Different therapeutic strategies and their underlying mechanisms are explored, with a focus on optimizing parameters for seizure reduction. The review also highlights the paradigm shift toward a more diverse and multimodal approach to deep brain neuromodulation.

Keywords: electrical stimulation; neuromodulation; seizure; suppression.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Ren Y, Cong F, Ristaniemi T, Wang Y, Li X, Zhang R. Transient seizure onset network for localization of epileptogenic zone: effective connectivity and graph theory-based analyses of ECoG data in temporal lobe epilepsy. J Neurol. 2019;266(4):844–859. doi:10.1007/s00415-019-09204-4 - PubMed
    1. Karoly PJ, Freestone DR, Eden D, et al. Epileptic seizure cycles: six common clinical misconceptions. Front Neurol. 2021;12:720328. https://www.frontiersin.org/articles/10.3389/fneur.2021.720328 - DOI - PMC - PubMed
    1. Liou JY, Smith EH, Bateman LM, et al. A model for focal seizure onset, propagation, evolution, and progression. Elife. 2020;9:1–27. doi:10.7554/eLife.50927 - PMC - PubMed
    1. Burns SP, Sritharan D, Jouny C, et al. A network analysis of the dynamics of seizure. Proc Annu Int Conf IEEE Eng Med Biol Soc EMBS. 2012;2012:4684–4687. doi:10.1109/EMBC.2012.6347012 - PubMed
    1. Fink M. Electrotherapeutics. J ECT. 2002;18(2):114–115. doi:10.1097/00124509-200206000-00014 - PubMed

LinkOut - more resources