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Review
. 2024 Jul;30(5):818-846.
doi: 10.1080/09297049.2023.2273573. Epub 2023 Oct 30.

Cognitive dysfunction in pediatric systemic lupus erythematosus: current knowledge and future directions

Ryan Kammeyer  1 , Ekemini A Ogbu  2   3 , Jennifer C Cooper  4 , Erin Stolz  5 , Amanda L Piquet  6 , Robert C Fuhlbrigge  4 , Jeffrey L Bennett  7 , Christa Hutaff-Lee  8
Affiliations
Review

Cognitive dysfunction in pediatric systemic lupus erythematosus: current knowledge and future directions

Ryan Kammeyer et al. Child Neuropsychol. 2024 Jul.

Abstract

Cognitive dysfunction (CD) is a neurologic complication of pediatric systemic lupus erythematosus (SLE) that remains poorly understood and understudied, despite the potential negative effects of CD on long-term socioeconomic status and quality of life. Data regarding the prevalence and risk factors for CD in pediatric SLE as well as the optimal screening, treatment, and long-term outcomes for CD are lacking. In this review, we present current knowledge on CD in pediatric SLE with a focus on the application to clinical practice. We discuss the challenges in diagnosis, clinical screening methods, potential impacts, and interventions for this complication. Finally, we discuss the remaining gaps in our knowledge of CD in pediatric SLE, and avenues for future research efforts.

Keywords: Cognitive dysfunction; autoimmune disease; cognitive impairment; neuropsychiatric lupus; pediatric systemic lupus erythematosus.

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Conflict of interest statement

Disclosure statement

No potential conflict of interest was reported by the author(s).

References

    1. ACR. (1999). The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis & Rheumatism, 42(4), 599–608. - PubMed
    1. AlE’ed A, Vega-Fernandez P, Muscal E, Hinze CH, Tucker LB, Appenzeller S, Bader-Meunier B, Roth J, Torrente-Segarra V, Klein-Gitelman MS, Levy DM, Roebuck-Spencer T, & Brunner HI (2017). Challenges of diagnosing cognitive dysfunction with neuropsychiatric systemic lupus erythematosus in childhood. Arthritis Care & Research, 69 (10), 1449–1459. 10.1002/acr.23163 - DOI - PMC - PubMed
    1. Ameer MA, Chaudhry H, Mushtaq J, Khan OS, Babar M, Hashim T, Zeb S, Tariq MA, Patlolla SR, Ali J, Hashim SN, & Hashim S (2022). An overview of systemic lupus erythematosus (SLE) pathogenesis, classification, and management. Cureus, 14(10), e30330. 10.7759/cureus.30330 - DOI - PMC - PubMed
    1. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. (1999). Arthritis & Rheumatism, 42(4), 599–608. 10.1002/1529-0131(199904)42:4<599:AID-ANR2>3.0.CO;2-F - DOI - PubMed
    1. Andersson U, & Lyxell B (2007). Working memory deficit in children with mathematical difficulties: A general or specific deficit? Journal of Experimental Child Psychology, 96(3), 197–228. 10.1016/j.jecp.2006.10.001 - DOI - PubMed

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