Eosinophilic granulomatosis with polyangiitis onset in severe asthma patients on monoclonal antibodies targeting type 2 inflammation: Report from the European EGPA study group

Marco Caminati¹, Angelo Fassio², Federico Alberici³, Chiara Baldini⁴, Federica Bello⁵, Paolo Cameli⁶, Edoardo Conticini⁷, Vincent Cottin⁸, Claudia Crimi^{9

10}, Lorenzo Dagna¹¹, Paolo Delvino^{12

13}, Alban Deroux¹⁴, Emine Duran¹⁵, Georgina Espigol-Frigole¹⁶, Omer Karadag¹⁵, Matteo Maule¹⁷, Sergey Moiseev¹⁸, Sara Monti^{12

13}, Luca Moroni¹¹, Roberto Padoan¹⁹, Gregory Pugnet²⁰, Camille Taille²¹, Paola Toniati²², Augusto Vaglio^{23

24}, Giacomo Emmi^{5

25}

Affiliations

¹ Asthma Center and Allergy Unit, Department of Medicine, University and Integrated University Hospital of Verona, Verona, Italy.
² Rheumatology Unit, Department of Medicine, University of Verona and Verona University Hospital, Verona, Italy.
³ Nephrology Unit, University of Brescia, Azienda Socio Sanitaria Territoriale Spedali Civili, Brescia, Italy.
⁴ Department of Internal Medicine, U.O. Rheumatology, University of Pisa, Pisa, Italy.
⁵ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
⁶ Respiratory Diseases Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
⁷ Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
⁸ Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, University of Lyon, INRAE, Lyon, France.
⁹ Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
¹⁰ Respiratory Medicine Unit, AOU Policlinico "G. Rodolico-San Marco", Catania, Italy.
¹¹ Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Vita-Salute San Raffaele University and San Raffaele Hospital, Milan, Italy.
¹² Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
¹³ Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
¹⁴ Departement of Internal Medicine, CHU Grenoble-Alpes, Grenoble, France.
¹⁵ Division of Rheumatology, Department of Internal Medicine, Vasculitis Research Center, Hacettepe University School of Medicine, Ankara, Turkey.
¹⁶ Department of Autoimmune Diseases, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
¹⁷ Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy.
¹⁸ Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia.
¹⁹ Division of Rheumatology, Department of Medicine, University of Padova, Padova, Italy.
²⁰ Service de Médecine Interne et Immunologie Clinique, CHU Rangueil, Toulouse, France.
²¹ Respiratory Diseases Department, Rare Pulmonary Diseases Reference Centre, Bichat Hospital, Paris Cité University, Paris, France.
²² Rheumatology and Clinical Immunology Unit, ASST Spedali Civili Brescia, Brescia, Italy.
²³ Nephrology and Dialysis Unit, Meyer Children's University Hospital - IRCCS, Firenze, Italy.
²⁴ Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Firenze, Italy.
²⁵ Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.

PMID: 37904674
DOI: 10.1111/all.15934

Free article

Eosinophilic granulomatosis with polyangiitis onset in severe asthma patients on monoclonal antibodies targeting type 2 inflammation: Report from the European EGPA study group

Marco Caminati et al. Allergy. 2024 Feb.

Free article

. 2024 Feb;79(2):516-519.

doi: 10.1111/all.15934. Epub 2023 Oct 31.

Authors

Affiliations

¹ Asthma Center and Allergy Unit, Department of Medicine, University and Integrated University Hospital of Verona, Verona, Italy.
² Rheumatology Unit, Department of Medicine, University of Verona and Verona University Hospital, Verona, Italy.
³ Nephrology Unit, University of Brescia, Azienda Socio Sanitaria Territoriale Spedali Civili, Brescia, Italy.
⁴ Department of Internal Medicine, U.O. Rheumatology, University of Pisa, Pisa, Italy.
⁵ Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
⁶ Respiratory Diseases Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
⁷ Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
⁸ Coordinating Reference Center for Rare Pulmonary Diseases, Louis Pradel Hospital, University of Lyon, INRAE, Lyon, France.
⁹ Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
¹⁰ Respiratory Medicine Unit, AOU Policlinico "G. Rodolico-San Marco", Catania, Italy.
¹¹ Unit of Immunology, Rheumatology, Allergy and Rare Diseases, Vita-Salute San Raffaele University and San Raffaele Hospital, Milan, Italy.
¹² Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
¹³ Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
¹⁴ Departement of Internal Medicine, CHU Grenoble-Alpes, Grenoble, France.
¹⁵ Division of Rheumatology, Department of Internal Medicine, Vasculitis Research Center, Hacettepe University School of Medicine, Ankara, Turkey.
¹⁶ Department of Autoimmune Diseases, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
¹⁷ Allergy Unit and Asthma Center, Verona University Hospital, Verona, Italy.
¹⁸ Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Moscow, Russia.
¹⁹ Division of Rheumatology, Department of Medicine, University of Padova, Padova, Italy.
²⁰ Service de Médecine Interne et Immunologie Clinique, CHU Rangueil, Toulouse, France.
²¹ Respiratory Diseases Department, Rare Pulmonary Diseases Reference Centre, Bichat Hospital, Paris Cité University, Paris, France.
²² Rheumatology and Clinical Immunology Unit, ASST Spedali Civili Brescia, Brescia, Italy.
²³ Nephrology and Dialysis Unit, Meyer Children's University Hospital - IRCCS, Firenze, Italy.
²⁴ Department of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Firenze, Firenze, Italy.
²⁵ Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.

PMID: 37904674
DOI: 10.1111/all.15934

No abstract available

Keywords: EGPA; T2 inflammation; benralizumab; dupilumab; eosinophilic granulomatosis with polyangiitis; mepolizumab; monoclonal antibodies; omalizumab; reslizumab; severe asthma.

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References

REFERENCES

1. Caminati M, Maule M, Bello F, Emmi G. Biologics for eosinophilic granulomatosis with polyangiitis. Curr Opin Allergy Clin Immunol. 2023;23(1):36-43.
1. Wechsler ME, Wong DA, Miller MK, Lawrence-Miyasaki L. Churg-strauss syndrome in patients treated with omalizumab. Chest. 2009;136(2):507-518.
1. Caminati M, Maule M, Nalin F, Senna G, Lunardi C. Onset of eosinophilic granulomatosis with polyangiitis in a patient treated with an IL-5 pathway inhibitor for severe asthma. Rheumatology (Oxford). 2021;60(2):e59-e60.
1. Caminati M, Olivieri B, Dama A, et al. Dupilumab-induced hypereosinophilia: review of the literature and algorithm proposal for clinical management. Expert Rev Respir Med. 2022;16(7):713-721.
1. Grayson PC, Ponte C, Suppiah R, et al. 2022 American College of Rheumatology/European Alliance of associations for rheumatology classification criteria for eosinophilic granulomatosis with polyangiitis. Arthritis Rheumatol. 2022;74(3):386-392.

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Eosinophilic granulomatosis with polyangiitis onset in severe asthma patients on monoclonal antibodies targeting type 2 inflammation: Report from the European EGPA study group

Affiliations

Eosinophilic granulomatosis with polyangiitis onset in severe asthma patients on monoclonal antibodies targeting type 2 inflammation: Report from the European EGPA study group

Authors

Affiliations

References

REFERENCES

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical