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. 2023 Nov-Dec;37(6):2473-2479.
doi: 10.21873/invivo.13354.

Expression of miRNA-451 and miRNA-885 in Meningiomas

Ozgur Baran  1 , Adil Can Karaoglu  1 , Erdogan Kara  2 , Orhan Budun  3 , Salim Katar  4 , Seda Guleç Yilmaz  5 , Fatma Tuba Akdeniz  5 , Mehmet Akif Ambarcioglu  6 , Nail Demirel  7 , Okan Turk  7 , Nuriye Güzin Ozdemir  7 , Cumhur Kaan Yaltirik  8 , Turgay Isbir  9
Affiliations

Expression of miRNA-451 and miRNA-885 in Meningiomas

Ozgur Baran et al. In Vivo. 2023 Nov-Dec.

Abstract

Background/aim: Meningiomas are one of the most common intracranial tumors, accounting for 30% of the tumors of the central nervous system. MicroRNAs (miRNAs) are noncoding RNAs containing approximately 18-22 nucleotides that regulate gene expression by interfering with transcription or inhibiting translation. Recent studies have reported that miRNAs could provide information about the molecular pathogenesis of several types of tumors. This study aimed to examine the expression levels of miRNA-885 and -451 and to determine their potential roles as biomarkers in meningioma.

Materials and methods: In total, 29 patients with meningioma (9 males and 20 females) were included in this study. The expression levels of miRNA were determined using real-time polymerase chain reaction. In addition, receiver operating characteristic curve analysis was used to analyze the predictive potential of miRNAs.

Results: Our results indicated a significant increase in miRNA-451 expression levels (p=0.003); however, there was no significant change in miRNA-885 expression levels (p=0.139) in patients with meningioma compared with the control group. Moreover, miRNA-885 and miRNA-451 expression levels did not differ significantly based on the histopathological grade of meningioma.

Conclusion: miRNA-451 may be a novel potential marker for the diagnosis and prognosis, and a target for meningioma treatment.

Keywords: Meningiomas; gene expression; microRNA-451; microRNA-885; neuro-oncology.

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Conflict of interest statement

The Authors declare that they have no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1. Comparison of miRNA-885 expression levels between the meningioma and control groups. Differences between the two groups were analyzed using the Mann-Whitney U-test. *p-value <0.05.
Figure 2
Figure 2. Comparison of miRNA-451 expression levels between the meningioma and control groups based on fold change. Differences between the two groups were analyzed using the Mann-Whitney U-test. *p-value <0.05.
Figure 3
Figure 3. ROC analysis graph of miRNA-451 expression levels in the control and meningioma groups. *p-value <0.05.
See this image and copyright information in PMC

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