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Review
. 2023 Dec;15(4):265-280.
doi: 10.1007/s12560-023-09568-x. Epub 2023 Oct 31.

Antiviral Natural Products, Their Mechanisms of Action and Potential Applications as Sanitizers and Disinfectants

Stephanie A Boone  1 , M Khalid Ijaz  2 , Kelly R Bright  3 , Norma Patricia Silva-Beltran  3 , Raymond W Nims  4 , Julie McKinney  2 , Charles P Gerba  3
Affiliations
Review

Antiviral Natural Products, Their Mechanisms of Action and Potential Applications as Sanitizers and Disinfectants

Stephanie A Boone et al. Food Environ Virol. 2023 Dec.

Abstract

Plant extracts, natural products and plant oils contain natural virucidal actives that can be used to replace active ingredients in commercial sanitizers and disinfectants. This review focuses on the virucidal mechanisms of natural substances that may exhibit potential for indoor air and fomite disinfection. Review of scientific studies indicates: (1) most natural product studies use crude extracts and do not isolate or identify exact active antiviral substances; (2) many natural product studies contain unclear explanations of virucidal mechanisms of action; (3) natural product evaluations of virucidal activity should include methods that validate efficacy under standardized disinfectant testing procedures (e.g., carrier tests on applicable surfaces or activity against aerosolized viruses, etc.). The development of natural product disinfectants requires a better understanding of the mechanisms of action (MOA), chemical profiles, compound specificities, activity spectra, and the chemical formulations required for maximum activity. Combinations of natural antiviral substances and possibly the addition of synthetic compounds might be needed to increase inactivation of a broader spectrum of viruses, thereby providing the required efficacy for surface and air disinfection.

Keywords: Antiviral; Disinfectants; Mechanism of action; Natural plant products; Sanitizers; Viruses.

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References

    1. Almeida, C. F., Purcell, D. F. J., Godfrey, D. I., & McAuley, J. L. (2022). The efficacy of common household cleaning agents for SARS-CoV-2 infection control. Viruses, 14(4), 715. https://doi.org/10.3390/v14040715 - DOI - PubMed - PMC
    1. Astani, A., & Schnitzler, P. (2014). Antiviral activity of monoterpenes beta-pinene and limonene against herpes simplex virus in vitro. Iranian Journal of Microbiology, 6(3), 149–155. https://ijm.tums.ac.ir/index.php/ijm/article/view/427 . - PubMed - PMC
    1. Astani, A., Reichling, J., & Schnitzler, P. (2009). The inhibitory effect of monoterpene, phenylpropanoid, sesquiterpene components of essential oils against herpes simplex virus. Planta Medica, 75(09), PF4. https://doi.org/10.1055/s-0029-1234646 . - DOI
    1. Astani, A., Reichling, J., & Schnitzler, P. (2010). Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Phytotherapy Research, 24(5), 673–679. https://doi.org/10.1002/ptr.2955 . - DOI - PubMed
    1. Astani, A., Reichling, J., & Schnitzler, P. (2011). Screening for antiviral activities of isolated compounds from essential oils. Evidence-Based Complementary and Alternative Medicine, (2011), 253643. https://doi.org/10.1093/ecam/nep187 - DOI - PubMed - PMC

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