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. 2023 Dec 14;18(24):e202300805.
doi: 10.1002/asia.202300805. Epub 2023 Nov 9.

Photoredox Metal-Free Synthesis of Unnatural β-Silyl-α-Amino Acids via Hydrosilylation

Guo-Qin Wang  1 , Ting Wang  1 , Yue Zhang  1 , Yuan-Xia Zhou  1 , Dan Yang  1 , Pan Han  1 , Lin-Hai Jing  1
Affiliations

Photoredox Metal-Free Synthesis of Unnatural β-Silyl-α-Amino Acids via Hydrosilylation

Guo-Qin Wang et al. Chem Asian J. .

Abstract

An efficient, practical and metal-free methodology for the synthesis of β-silyl-α-amino acid motifs via photoredox and hydrogen atom transfer (HAT) process is described. This protocol enables the direct hydrosilylation of dehydroalanine derivatives and tolerates a wide array of functional groups and synthetic handles, leading to valuable β-silyl-α-amino acids with moderate to good yields.

Keywords: hydrosilylation; metal-free; photoredox; radical reactions; β-silyl-α-amino acid.

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