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. 2023 Nov 1;46(1):289.
doi: 10.1007/s10143-023-02191-1.

Outcomes of the early endoscopic-assisted suturectomy for treatment of multisuture craniosynostosis

Omid Yousefi  1 , Reza Taheri  1 , Mohammadmahdi Sabahi  2 , Rebecca A Reynolds  3 , Amirmohamad Farrokhi  1 , Sina Zoghi  1 , Arash Jamshidi  1 , Mohammad Ali Hoghoughi  4 , M Omar Iqbal  5 , George I Jallo  6 , Mohammad Sadegh Masoudi  7
Affiliations

Outcomes of the early endoscopic-assisted suturectomy for treatment of multisuture craniosynostosis

Omid Yousefi et al. Neurosurg Rev. .

Abstract

To present the outcomes and adverse events associated with the endoscopic-assisted, minimally invasive suturectomy in patients with multisuture synostosis. This retrospective cohort study included children < 65 days of age who underwent endoscopic-assisted suturectomy (EAS) for multisuture craniosynostosis at a single tertiary referral center from 2013 to 2021. The primary outcome was calvarial expansion, and the secondary outcome was adverse events. The pre- and post-operative 3-dimensional brain computed tomography (CT) scan was used to calculate the intracranial volume and cephalic index. During a period of 2 years, 10 infants (10-64 days) diagnosed with multisuture synostosis underwent single-stage EAS of every affected suture in our center. The coronal suture was the most prevalent involved suture among our cases. The mean age and weight of the patients were 39 ± 17.5 days and 4.39 ± 0.8 kg, respectively. The surgical procedure took 42 ± 17.4 min of time and caused 46 ± 25.4 mL of bleeding on average. Ninety percent of the operations were considered successful (n = 9) regarding calvarial expansion. There were two complications, one requiring an open vault surgery and one repairing a leptomeningeal cyst. In the eight patients who did not necessitate further interventions, the mean pre-operative intracranial volume was 643.3 ± 189.4 cm3. The follow-up results within the average of 38.9 months after surgery showed that as age increases, the intracranial volume also increased significantly (R: 0.6, P < 0.0001), which suggests continued skull growth in patients who underwent EAS. With the low rate of intra- or post-operative complications and promising results on revising the restricted skull sutures, EAS seems both a safe and effective therapeutic modality in patients with multisuture synostosis, especially if completed in the first months after birth.

Keywords: Helmet therapy; Minimally invasive suterectomy; Multisuture craniosynostosis.

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References

    1. Manjila S, Chim H, Eisele S, Chowdhry SA, Gosain AK, Cohen AR (2010) History of the Kleeblattschädel deformity: origin of concepts and evolution of management in the past 50 years. Neurosurg Focus 29(6):E7 - DOI - PubMed
    1. Yilmaz E, Mihci E, Nur B, Alper ÖM, Taçoy Ş (2019) Recent advances in craniosynostosis. Pediatr Neurol 99:7–15 - DOI - PubMed
    1. Davis C, Lauritzen CG (2009) Frontobasal suture distraction corrects hypotelorism in metopic synostosis. J Craniofac Surg 20(1):121–124 - DOI - PubMed
    1. Stanton E, Urata M, Chen J-F, Chai Y (2022) The clinical manifestations, molecular mechanisms and treatment of craniosynostosis. Dis Model Mech 15(4):dmm049390
    1. Mehta VA, Bettegowda C, Jallo GI, Ahn ES (2010) The evolution of surgical management for craniosynostosis. Neurosurg Focus 29(6):E5 - DOI - PubMed

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