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Case Reports
. 2023 Jun 28;1(3):luad062.
doi: 10.1210/jcemcr/luad062. eCollection 2023 May.

Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome

Tugce Akcan  1 , Julia Rose R Shariff  2
Affiliations
Case Reports

Recurrent Hypoglycemia Secondary to Insulinoma in an Adult With Beckwith-Wiedemann Syndrome

Tugce Akcan et al. JCEM Case Rep. .

Abstract

Beckwith-Wiedemann syndrome (BWS) is a rare genetic disorder characterized by genetic and epigenetic changes on the chromosome 11p15.5 region, which includes genes that are important for fetal and postnatal growth. Children with BWS have a higher chance of having hypoglycemia, hyperinsulinemia, and malignancies early in life, although hypoglycemia caused by an insulinoma that develops later in life has not been reported. We describe the diagnosis of insulinoma in a 53-year-old man with BWS in this case report. This is the first case report of insulinoma in an adult with this syndrome.

Keywords: beckwith-wiedemann syndrome; heart failure; hyperinsulinemia; hypoglycemia; insulinoma.

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Figures

Figure 1.
Figure 1.
(A) Computed tomography image of the abdomen, demonstrating a large heterogeneous enhancing insulinoma arising from the tail of the pancreas. (B) Magnetic resonance imaging scan of the abdomen revealing of a mass in the tail of the pancreas, which represents neuroendocrine tumor/insulinoma.
Figure 2.
Figure 2.
Histological sections of the insulinoma. (A) Histopathological appearance of insulinoma, hematoxylin and eosin. (B) Immunohistochemistry staining showing positivity of tumor cells for chromogranin. (C). Immunoperoxidase stain for Ki-67. (D) Immunohistochemical reaction for chromogranin.
See this image and copyright information in PMC

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