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. 2023 Apr;2(4):e221200.
doi: 10.7326/aimcc.2022.1200. Epub 2023 Apr 18.

Rifampin-Associated Renal Failure

Affiliations

Rifampin-Associated Renal Failure

Kathleen Miller et al. Ann Intern Med Clin Cases. 2023 Apr.

Abstract

Rifampin is an effective and widely used for the treatment of both active and latent tuberculosis. Although significant side effects are rare, severe side effects such as acute renal failure have been reported in the literature, usually secondary to acute interstitial nephritis. We report a case of rifampin-induced acute renal failure due to heme pigment-related injury in a patient who was receiving daily rifampin as therapy for latent tuberculosis. The patient case illustrates considering rifampin as a potential cause of acute renal failure when no other cause is identified.

Keywords: Acute renal failure; Bilirubin; Case series; Hemoglobin; Hemolytic anemia; Hospital medicine; Medical dialysis; Nephritis; Pigment associated nephropathy; Platelets; Renal failure; Rifampin; Tuberculosis.

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Figures

Figure 1.
Figure 1.
(A) Many tubules in the cortex contain eosinophilic proteinaceous material and cell debris (hematoxylin–eosin stain 20× objective). (B) The content of these tubules shows strong reactivity for hemoglobin by immunohistochemistry (immunoperoxidase stain, 20× objective).

References

    1. Chiba S, Tsuchiya K, Sakashita H, et al. Rifampicin-induced acute kidney injury during the initial treatment of pulmonary tuberculosis: a case report and literature review. Intern Med. 2013;52:2457–60. doi:10.2169/internalmedicine.52.0634 - DOI - PubMed
    1. Sakashita K, Murata K, Takahashi Y, et al. A case series of acute kidney injury during antituberculosis treatment. Intern Med. 2019;58:521–7. doi:10.2169/internalmedicine.0813-18 - DOI - PMC - PubMed
    1. Covic A, Golea O, Segall L, et al. A clinical description of rifampicin-induced acute renal failure in 170 consecutive cases. J Indian Med Assoc. 2004;102:20–2. - PubMed
    1. Schubert C, Bates WD, Moosa MR. Acute tubulointerstitial nephritis related to antituberculous drug therapy. Clin Nephrol. 2010;73:413–9. doi:10.5414/cnp73413 - DOI - PubMed
    1. Muthukumar T, Jayakumar M, Fernando EM, et al. Acute renal failure due to rifampicin: a study of 25 patients. Am J Kidney Dis. 2002;40:690–6. doi:10.1053/ajkd.2002.35675 - DOI - PubMed

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