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. 2024 May;134(5):2295-2299.
doi: 10.1002/lary.31146. Epub 2023 Nov 1.

Demographics and Clinical Characteristics Associated with the Spread of New-Onset Laryngeal Dystonia

Arian Ghanouni  1 , Nikitha Jona  2 , Hyder A Jinnah  3 , Gamze Kilic-Berkmen  3 , Sandeep Shelly  4 , Adam M Klein  4
Affiliations

Demographics and Clinical Characteristics Associated with the Spread of New-Onset Laryngeal Dystonia

Arian Ghanouni et al. Laryngoscope. 2024 May.

Abstract

Objectives: Adult-onset idiopathic laryngeal dystonia (LD) can be associated with the risk of spread to muscles in the body. Subjects with extralaryngeal onset of dystonia have exhibited spread to the larynx. Previous studies analyze the spread of other dystonias but emphasis has not been placed on LD. The objective was to identify demographic and clinical factors contributing to the spread of dystonia to and from the larynx.

Methods: Data were obtained from the Dystonia Coalition (DC)-patients from 49 international clinical centers. Clinical and demographic data was taken from 143 out of 409 patients with diagnosed LD. Patient criteria included adult-onset LD diagnosed on exam with no co-morbid neurologic conditions and no dystonia in other locations.

Results: Among the 143 patients, 94 (65.7%) patients were diagnosed with focal laryngeal onset, with the remainder having extralaryngeal onset. Family history and age at study were statistically significant indicators of a patient developing laryngeal versus extralaryngeal onset of dystonia. Among the laryngeal onset group, 21 cases (22.3%) had an average time of 5.81 ± 5.79 years to spread from diagnosis, most commonly to neck (61.9%). Among extralaryngeal onset patients, mean time of larynx spread was 7.92 ± 7.737 years, most commonly to neck (22.7%).

Conclusions: Our data indicates approximately a quarter of patients with laryngeal-onset dystonia will exhibit spread. There were no demographic or clinical factors that were statistically predictive of the likelihood of spread from larynx. Patients with dystonia elsewhere in the body should be counseled on the possibility of spread to larynx, and vice versa.

Level of evidence: 4 Laryngoscope, 134:2295-2299, 2024.

Keywords: dystonia; laryngeal dystonia; larynx.

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Conflict of interest statement

The authors have no financial relationships or conflicts of interest to disclose.

Figures

Fig. 1.
Fig. 1.
Kaplan–Meier Plot: spread to another anatomical site.
See this image and copyright information in PMC

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