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. 2023 Jul 16;9(4):341-344.
doi: 10.1002/cdt3.81. eCollection 2023 Dec.

Pure red cell aplasia and minimal residual disease conversion associated with immune reconstitution in a patient with high-risk multiple myeloma

Xianghong Jin  1   2 , Xianyong Jiang  1 , Wei Wang  1 , Shuangjiao Liu  1 , Bing Han  1 , Jianhua Han  3 , Junling Zhuang  1
Affiliations

Pure red cell aplasia and minimal residual disease conversion associated with immune reconstitution in a patient with high-risk multiple myeloma

Xianghong Jin et al. Chronic Dis Transl Med. .

Abstract

A second bone marrow aspiration and biopsy showed pure red cell aplasia in this case.

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Conflict of interest statement

Professor Junling Zhuang is a member of the Chronic Diseases and Translational Medicine editorial board and is not involved in the peer review process of this article. The remaining authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The OB evolution figures. (A) λ light chain isotype was present at diagnosis (2019‐8). (B) IFE detection was negative before ASCT (2020‐4). (C) A new monoclonal component was identified at 3 months after ASCT (2020‐9). (D) The OB disappeared at 5 months after maintenance therapy (2021‐2). ASCT, autologous stem cell transplantation; IFE, immunofixation electrophoresis; OB, oligoclonal bands.
Figure 2
Figure 2
A second bone marrow aspiration and biopsy showed pure red cell aplasia in this case.
Figure 3
Figure 3
An illustration of the time course of the events (HDT, maintenance therapy, MRD f‐u, PRCA, cyclosporine, etc.). ASCT, autologous stem cell transplantation; BM, bone marrow aspiration; HDT, high‐dose therapy; HGB, hemoglobin; HSC, hematopoietic stem cells; MRD, minimal residual disease; OB, oligoclonal bands; PRCA, pure red cell aplasia; sCR, stringent complete response.
See this image and copyright information in PMC

References

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