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. 2025 Apr;17(2):873-887.
doi: 10.1007/s12602-023-10173-4. Epub 2023 Nov 2.

Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats

Nathalia da Silva Costa #  1 , Joana Ramos de Araujo #  2 , Manuela Fernandes da Silva Melo  3 , Jéssica da Costa Mota  3 , Patricia Pereira Almeida  4 , Karen Salve Coutinho-Wolino  5 , Beatriz Oliveira Da Cruz  5 , Michele Lima Brito  4 , Thaís de Souza Carvalho  6 , Emanuelle Barreto-Reis  4   6 , Beatriz Gouvêa de Luca  4   6 , Denise Mafra  7   8 , D 'Angelo Carlo Magliano  4   6 , Renato de Souza Abboud  9 , Ramon Silva Rocha  10 , Adriano Gomes da Cruz  10   11 , Jonas de Toledo Guimarães  12 , Milena Barcza Stockler-Pinto  5   7   3   4
Affiliations

Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats

Nathalia da Silva Costa et al. Probiotics Antimicrob Proteins. 2025 Apr.

Abstract

Dairy foods have become an interest in chronic kidney disease (CKD) due to their nutritional profile, which makes them a good substrate for probiotics incorporation. This study evaluated the effect of probiotic-enriched Minas cheese with Lactobacillus acidophilus La-05 in an experimental rat model for CKD on cardiac, inflammatory, and oxidative stress parameters. Male Wistar rats were divided into 4 groups (n = 7/group): 5/6 nephrectomy + conventional Minas cheese (NxC); 5/6 nephrectomy + probiotic Minas cheese (NxPC); Sham + conventional Minas cheese (ShamC); Sham + probiotic Minas cheese (ShamPC). Offering 20 g/day of Minas cheese with Lact. acidophilus La-05 (108-109 log CFU/g) for 6 weeks. The cardiomyocyte diameter was determined. Superoxide dismutase (SOD) activity in plasma, heart, kidney, and colon tissue was performed. At the end of supplementation, no significant changes in lipid profile and renal parameters were found. The NxPC group showed a decrease in cardiomyocyte diameter compared to the NxC group (16.99 ± 0.85 vs. 19.05 ± 0.56 μm, p = 0.0162); also they showed reduced plasmatic SOD activity (502.8 ± 49.12 vs. 599.4 ± 94.69 U/mL, p < 0.0001). In summary, probiotic-enriched Minas cheese (Lact. acidophilus La-05) consumption suggests a promisor cardioprotective effect and was able to downregulate SOD activity in a rat model of CKD.

Keywords: Lactobacillus acidophilus La-05; Cardiac hypertrophy; Chronic kidney disease; Inflammation; Oxidative stress; Probiotics cheese.

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Conflict of interest statement

Declarations. Competing Interests: The authors declare no competing interests.

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