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Review
. 2023 Oct 18:14:1274686.
doi: 10.3389/fendo.2023.1274686. eCollection 2023.

Sestrin2 in diabetes and diabetic complications

Xiaodan Zhang  1 , Zirui Luo  2 , Jiahong Li  2 , Yaxuan Lin  2 , Yu Li  1 , Wangen Li  1
Affiliations
Review

Sestrin2 in diabetes and diabetic complications

Xiaodan Zhang et al. Front Endocrinol (Lausanne). .

Abstract

Diabetes is a global health problem which is accompanied with multi-systemic complications. It is of great significance to elucidate the pathogenesis and to identify novel therapies of diabetes and diabetic complications. Sestrin2, a stress-inducible protein, is primarily involved in cellular responses to various stresses. It plays critical roles in regulating a series of cellular events, such as oxidative stress, mitochondrial function and endoplasmic reticulum stress. Researches investigating the correlations between Sestrin2, diabetes and diabetic complications are increasing in recent years. This review incorporates recent findings, demonstrates the diverse functions and regulating mechanisms of Sestrin2, and discusses the potential roles of Sestrin2 in the pathogenesis of diabetes and diabetic complications, hoping to highlight a promising therapeutic direction.

Keywords: Sestrin2; diabetes; diabetic complications; mitochondrial function; oxidative stress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Sestrin2 and Diabetes.
Figure 2
Figure 2
Sestrin2 and Diabetic kidney disease.
Figure 3
Figure 3
Sestrin2 and Diabetic heart disease.
See this image and copyright information in PMC

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