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Review
. 2023 Oct 21;9(11):e21205.
doi: 10.1016/j.heliyon.2023.e21205. eCollection 2023 Nov.

Promising role of Vitamin D and plant metabolites against COVID-19: Clinical trials review

Rupanshee Srivastava  1 , Nidhi Singh  1 , Tripti Kanda  1 , Sadhana Yadav  1 , Shivam Yadav  2 , Piyush Choudhary  3 , Neelam Atri  1
Affiliations
Review

Promising role of Vitamin D and plant metabolites against COVID-19: Clinical trials review

Rupanshee Srivastava et al. Heliyon. .

Abstract

Vitamin D possesses immunomodulatory qualities and is protective against respiratory infections. Additionally, it strengthens adaptive and cellular immunity and boosts the expression of genes involved in oxidation. Experts suggested taking vitamin D supplements to avoid and treat viral infection and also COVID-19, on the other hand, since the beginning of time, the use of plants as medicines have been vital to human wellbeing. The WHO estimates that 80 % of people worldwide use plants or herbs for therapeutic purposes. Secondary metabolites from medicinal plants are thought to be useful in lowering infections from pathogenic microorganisms due to their ability to inhibit viral protein and enzyme activity by binding with them. As a result, this manuscript seeks to describe the role of vitamin D and probable plant metabolites that have antiviral activities and may be complementary to the alternative strategy against COVID-19 in a single manuscript through reviewing various case studies.

Keywords: COVID-19; Clinical trials; Medicinal plants and Vitamin D.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Vitamin D synthesis and its advantages.
Fig. 2
Fig. 2
Structural proteins of SARS-CoV-2 and their functions.
Fig. 3
Fig. 3
Risk factors associated with Vitamin D insufficiency leading to increased susceptibility to COVID-19.
Fig. 4
Fig. 4
Low Level of Vitamin D leads to increase risk in COVID-19 infection resulting in higher mortality rate as reported by Padhi et al., 2020.
Fig. 5
Fig. 5
COVID-19 survival rate of Comparator and Intervention group (Annweiler et al., 2020).
Fig. 6
Fig. 6
Digrammatic representation of the case study of Arogyam, 2020 comparing the ayurvedic treatment with conventional treatment.
Fig. 7
Fig. 7
Oral administration of Ashwagandha, giloy and tulsi tablets helped in relieving COVID-19 symptoms (Kulkarni et al., 2021).
Fig. 8
Fig. 8
Role of Allium and Scutellaria baicalensinin preventing COVID-19 infection by inhibiting contact of SAR-CoV-2 to the ACE2 receptor.
Fig. 9
Fig. 9
Mode of action of Vitamin D and Plant metabolites in combating COVID-19.
See this image and copyright information in PMC

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